Effects of chronic administration of norharman on spatial learning and memory in female rats

Mohammad-Hossein Esmaili; M Hassani; M Ashouri; R Amanea goragi; F Mosavi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Effects of chronic administration of norharman on spatial learning and memory in female rats

Author(s):

Mohammad-Hossein Esmaili^,*,

M Hassani¹,

M Ashouri¹,

R Amanea goragi¹,

F Mosavi²

1Qazvin university of medical science

2medical science

Journal of Inflammatory Diseases:Vol. 18, issue 2; 39-45

Article type:Research Article

How to Cite:Mohammad-Hossein EsmailiM HassaniM AshouriR Amanea goragiF MosaviEffects of chronic administration of norharman on spatial learning and memory in female rats.J Inflamm Dis.18(2):e155828.

Abstract

Background: The exogenous and endogenous β-carbolines , and some of their metabolites have a stimulating effect on the dopaminergic system. β-carbolines can also improve learning and memory while increase hippocampal dopamine levels and dendritic and synaptic proliferation . Objective: The aim of this study was to investigate the effects of chronic administration of norharman on spatial learning and memory in rats. Methods: In this experimental study, 48 f emale wistar rats were randomly divided into control, alchohol and 4 norharmane groups. The control group were received no treatment. In alchohol and norharman groups, rats were received 0.2 ml alchohol or 1, 2, 3 or 4 mg/kg norharman intraperitoneally for 5 days before tests and 5 days during tests. All rates were tested for spatial learning and memory in the Morris water maze. Data were analyzed using student T-test, one way ANOVA and LSD as post hoc test. Findings: N orharman improved spatial learning in a dose dependent manner. T he difference between the 4 mg/kg norharman group and the control group was statistically significant in the 2nd day . N orharman also improved spatial memory in which lower doses improved spatial memory more than higher doses. T he difference between the 2 mg/kg and 4 mg/kg norharman groups was statistically significant. Conclusion: With regards to the results, norharman as an endogenous bioactive molecule, might have a key role in the modulation of learning and memory functions.

Keywords

Norharman

Learning

Memory

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