Abstract
Background: Oral Lichen Planus (OLP) is an inflammatory condition with unknown etiology. Reactive oxygen species (ROS) and free radicals may play an important role in the pathogenesis of this disease. Objective: The aim of this study was to compare salivary lipid peroxidation in patients with oral lichen planus with healthy subjects. Methods: This case-control study was conducted in Zahedan School of Dentistry during 2014-15. Unstimulated saliva samples were collected from 30 patients with OLP and 30 age and gender-matched healthy controls and were transferred to the laboratory. Salivary lipid peroxidation products were measured using TBARS (thiobarbituric acid reactive substance) method. Data were analyzed using Mann-Whitney U test. Findings : Salivary lipid peroxidation in patients with OLP was significantly higher than healthy controls (1.57±0.63 µM vs. 1.2 ± 0.77µM ) . Mean Salivary lipid peroxidation in women with OLP was significantly higher than healthy women (1.67±0.67 µM vs. 1.16±0.82 µM ). Conclusion: With regards to the results, it seems that lipid peroxidation in patients with OLP is higher than healthy subjects.
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Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.