Effect of potassium channel blocker  of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats

Hashem Haghdoost-Yazdi; Soheila sehat bakhsh; Mohammad Sofiabadi; Tahereh Dargahi; MH Yaghubidust; Hossein Piri

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats

Author(s):

Hashem Haghdoost-Yazdi,

Soheila sehat bakhsh,

Mohammad Sofiabadi,

Tahereh Dargahi,

MH Yaghubidust,

Hossein Piri^,*

Journal of Inflammatory Diseases:Vol. 20, issue 2; 48-41

Article type:Research Article

How to Cite:Hashem Haghdoost-YazdiSoheila sehat bakhshMohammad SofiabadiTahereh DargahiMH YaghubidustHossein Piriet al.Effect of potassium channel blocker of Tetraethylammonium pretreatment on prevention of the 6-OHDA-induced chronic Parkinson\'s disease in rats.J Inflamm Dis.20(2):e155962.

Abstract

Background: Nuclease and caspase activities that promote death signals and cause apoptosis are dependent to potassium ion. Objective: The aim of this study was to investigate the effect of potassium channel blocker tetraethylammonium (TEA) on prevention of Parkinson;#39s disease in rats. Methods: This experimental study was conducted on 33 male rats in Qazvin University of Medical Sciences, 2014. 6-hydroxydopamine (6-OHDA) was injected into the striatum of the brain. The rats received different doses of TEA twice daily the day before the 6-OHDA injection till 15 days after the injection. The severity of Parkinsonism was assessed by the apomorphine-induced rotational behavior, the elevated body swing test (EBST), and the rotarod test. Data were analyzed using Kruskal Wallis and Mann Whitney U tests. Findings: Pretreatment with 5 mg/kg TEA significantly reduced the severity of rotations compared to the saline group. TEA did not reduce the swings in the EBST. In the rotarod test, TEA caused significant improvement in the motor performance of the rats. Conclusion: With regards to the results, it seems that pretreatment with TEA can partly reduce the severity of behavioral symptoms in the 6-OHDA-induced chronic Parkinson;#39s disease. The higher the TEA dose, the more significant the reduction in the severity of symptoms.

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