Determining minimum inhibitory concentration growth rate and sensitivity of Yersinia to beta-lactam antibiotics

Mohammad Mehdi Soltan Dallal; MK Sharifi Yazdi; S Vahedi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Determining minimum inhibitory concentration growth rate and sensitivity of Yersinia to beta-lactam antibiotics

Author(s):

Mohammad Mehdi Soltan Dallal^,*,

MK Sharifi Yazdi,

S Vahedi

Journal of Inflammatory Diseases:Vol. 20, issue 5; 18-11

Article type:Research Article

How to Cite:Mohammad Mehdi Soltan DallalMK Sharifi YazdiS VahediDetermining minimum inhibitory concentration growth rate and sensitivity of Yersinia to beta-lactam antibiotics.J Inflamm Dis.20(5):e155987.

Abstract

Background: Diarrhea is one of the most important causes of children mortality in developing countries. Gastroenteritis causes mortality in children younger than five years old annually. The presence of antibiotics resistance species among these bacteria are major health problems. Objective: This study aimed to determine the antibiotic susceptibility and MIC50%, MIC90% of Yersinia to three beta-lactam antibiotics. Methods: This experimental study was determined sensitivity of different species of Yersinia to three beta-lactam antibiotics (Ampicillin-Cefazolin-Cefotaxime). In total 50 species (39 from different human sources, environments, foods and 11 from Pasteur institutions in Paris) were used. Minimum inhibitory concentration (MIC) was carried out by serial dilution method. Findings: Among three tested antibiotics, the lowest MIC 50%, MIC 90% were obtained for Cefotaxime (≥0.125μg/ml and 0.5μg/ml). All the tested species showed resistance to Ampicillin and very low sensitivity toward Cefazolin. Conclusion: The results showed that Cefotaxime was more effective against Yersinia species in compared to Ampicillin and Cefazolin.

Keywords

Yersinia spp

Beta lactam

minimum inhibitory concentration (MIC)

Ampicillin

Cefazolin

Cefotaxime

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