The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial

How to Cite:Arfa N, Allami A. The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial. J Inflamm Dis. 2024;21(6):e156059. doi:

Abstract

Background: According to national tuberculosis control guide, two-step tuberculin skin test (TST) should be done in the elderly, if the initial test is negative. However, it raises questions about the usefulness of this approach. Objective: This study aimed to explore the effects of fish oil supplements on the two-step tuberculin test in hospitalized patients. Methods: In this randomized controlled clinical trial, 128 patients randomly allocated to control group (receiving placebo, n=64) and treatment group (receiving fish oil supplements, n=64) during 2016. Fish oil supplement group was treated with 2 g daily for 4 consecutive days. The outcome was considered a change in 2 sequential TST induration sizes. Significant increase in the size of the secondary induration compared to primary was considered 6 mm or more. Findings: There was significant difference between primary and secondary indurations of two groups (higher in treatment group) (P=0.04). According to the results of analysis of variance and correlation tests, two effective factors were identified: initial induration and residence location (P=0.014 and P=0.002, respectively). In both groups, no clinically significant increase in the size of induration was observed. Conclusion: It seems that the number of cases considered as infected with tuberculosis does not increase with two- rather than one-step tuberculin skin test. Also, the short-term administration of fish oil supplements does not change this result.

Keywords

Fish oils

Polyunsaturated fatty acids

Dietary supplements

Tuberculin test

Clinical trial

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 3 weeks ago
Scopus by Title: 0
Last Update: 3 weeks ago
Scopus by Title (Ref): 0
Last Update: 3 weeks ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

N Arfa:[PubMed][Scholar]
Abbas Allami:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial

Abstract

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 3 weeks ago

Last Update: 3 days ago