Association between the HLA-G*0105N polymorphism and recurrent abortion in women

authors:

avatar zeinab hajifathaliya 1 , avatar Reza Najafipour , avatar MH Modarressi , * , avatar Shahram Savad , avatar zahra rashvand

Tehran University of Medical Sciences
Journal of Inflammatory Diseases: Vol.21, issue 6; 37-30
article type: issue_documents_importer

how to cite: hajifathaliya Z, Najafipour R, Modarressi M, Savad S, rashvand Z. Association between the HLA-G*0105N polymorphism and recurrent abortion in women. J Inflamm Dis. 2018;21(6):e156060. 

Abstract

Background: In human pregnancies HLA-G (Human leukocyte antigens G) is supposed that play a main role in implantation. It is expressed on trophoblast cells that invades during pregnancy to the uterus decidua and is introduced to induce maternal tolerance immunologically against the fetus. Objective: The aim of this study was to find association between the HLA-G*0105N polymorphism and recurrent abortion in women. Methods: This case-control study was conducted on two groups of 108 women with history recurrent abortion (RSA) as a case group or without history RSA as a control group in Cellular and Molecular Research Center, Qazvin University of Medical Sciences in 2015. The frequency of null allele of HLA-G*0105N was studied in two groups by PCR -RFLP method. Allele and genotype frequencies of two group were compared using Hardy-Weinberg equilibrium and Chi-square test. Findings: In case group, 54 (50%) and 17 (15.7%) were heterozygous and homozygous respectively for HLA-G*0105N polymorphism. In control group, only 9 (8%) was homozygous for HLA-G*0105N polymorphism. But there was no significant difference between case and control on HLA-G*0105N allele with RSA (P=0.1004). Conclusion: As the results, there was no significant association between HLA-G*0105N poly morphism and RSA. Thus, it seems that this HLA-G*0105N polymorphism may effective in relation with other genes or polymorphisms in RSA.