Plasmid-mediated quinolones resistance in clinically important bacteria

M Omidvar Panah; M Najafi; Amir Peymani

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

Plasmid-mediated quinolones resistance in clinically important bacteria

Author(s):

M Omidvar Panah¹,

M Najafi¹,

Amir Peymani^1,*

1Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Journal of Inflammatory Diseases:Vol. 22, issue 2; 90-99

Article type:Review Article

How to Cite:M Omidvar PanahM NajafiAmir PeymaniPlasmid-mediated quinolones resistance in clinically important bacteria.J Inflamm Dis.22(2):e156086.

Abstract

Quinolones are synthetic and commonly used antibiotics for treatment of multiple clinical infections in the world. Quinolones are clinically important antibiotics, as an ideal component, because of high potency, broad-spectrum activity, good bioavailability and a potentially low incidence of side-effects. These antibiotics are not originated from biological source. In addition to chromosomal mutations in the target genes which confer resistance to these antibiotics, in recent years, plasmids-mediated quinolone resistance (PMQR) have made difficult to treat infections caused by resistant organisms. PMQR plays a very important role in resistance to these antibiotics due to the rapid spread between the bacteria. So far, three types of PMQR have been identified, including the aac(6')-Ib-cr, the qepA efflux pump and the qnr proteins. In this research, the role of qnr proteins in the development of drug resistance to the quinolone compounds has been studied.

Keywords

Quinolone

Drug resistance

Qnr protein

comments