Abstract
Background Growth/Differentiation Factor-15 (GDF-15) is a stress responsive cytokine linked to obesity, cardiovascular disease and inflammation. Exercise can be a transient physiological stress in whole-body energy metabolism.
Objective The aim of this study was to evaluate the glucose, insulin and GDF-15 serum responses to acute effects of two intermittent and continuous exercises in sedentary obese males.
Methods In this quasi-experimental study, eight inactive men (Mean±SD age, 25.75±2.37 years, body mass index: 31.96±3.03 kg/m2) were asked to perform two types of high-intensity intermittent activity (HIIT, 6×1-min running with 85% VO2max intensity and 4-min rest with 60% VO2max intensity between sets) and moderate-intensity continuous exercise (MIT, 30-min running with 65% VO2max intensity) in a crossover and randomly designed protocol along with control session.
Findings GDF-15 serum level exercise significantly increased after HIIT and MIT exercises compared to the control (P≤0.001) and after 24 h, no significant difference was seen between the results of two groups (P>0.62). Serum glucose level significantly decreased after both HIIT and MIT protocols compared to the controls (P<0.001), but no significant differences were observed in insulin serum levels between protocols (P>0.13).
Conclusion Exercise can increase plasma GDF-15 level and improve glucose metabolism in inactive obese males.
Keywords
Aerobic exercises High-intensity intermittent exercises TGF-beta Superfamily Proteins Obesity
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.