Determining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension

Seyyed Mehdi Mirhashemi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

Determining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension

Author(s):

Seyyed Mehdi Mirhashemi^1,*

1Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 23, issue 5; 372-381

Article type:Research Article

How to Cite:Seyyed Mehdi MirhashemiDetermining Cardiometabolic and Antioxidant Effects of Olive Leaf Extract in Patients with Essential Hypertension.J Inflamm Dis.23(5):e156177.

Abstract

Background Hypertension is one of the most common clinical disorders affecting millions worldwide. Some studies have indicated the role of oxidative stress in the pathogenesis of hypertension and the importance of antioxidant compounds in their control. Objective The aim of this study was to evaluate the effects of olive leaf extract (OLE), Olea europaea L., on cardiometabolic parameters and biomarkers of oxidative stress in patients with essential hypertension. Methods This randomized double-blind placebo-controlled clinical trial conducted in 2017 on 60 patients with essential hypertension aged 30-60 years referred to the cardiovascular clinic of Bu-Ali Sina Hospital in Qazvin, Iran. The patients were randomly allocated into two groups of OLE (n=30; receiving OLE 250 mg capsules twice per day for 12 weeks) and placebo (n=30, receiving placebo drug for 12 weeks). Before and after intervention, cardiometabolic parameters and oxidative stress biomarkers were measured using appropriate laboratory methods. To compare variables and groups, paired-t test and independent t-test were used, respectively. Findings The OLE intake led to a significant decrease in systolic blood pressure, serum total cholesterol, and malondialdehyde levels in hypertensive patients compared to the placebo group, but significantly increased superoxide dismutase activity (P

Keywords

comments