Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Reza Najafipour; Sahar Moghbelinejad; abotorabi; Elnaz Riyazi; Leila Mokhber

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Association of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility

Author(s):

Reza Najafipour¹,

Sahar Moghbelinejad^1,*,

abotorabi²,

Elnaz Riyazi¹,

Leila Mokhber³

1Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.

2Department of Obstetrics and Gynecology, School of Medicine, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

3School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 23, issue 5; 382-395

Article type:Research Article

How to Cite:Reza NajafipourSahar Moghbelinejad abotorabiElnaz RiyaziLeila MokhberAssociation of the -308G/A Polymorphism of TNF-α Gene with Some Semen and Sperm Parameters in Men with Infertility.J Inflamm Dis.23(5):e156178.

Abstract

Background The tumor necrosis factor alpha (TNF-α) gene is a cytokine involved in systemic inflammation. Results of the association of its polymorphisms with infertility in men are controversial. Objective The aim of this study was to evaluate the association of -308G/A polymorphism in TNF-α gene with different parameters of semen and sperm in infertile men. Methods Participants were 210 men with infertility and 120 controls. The polymorphism evaluation was performed by sequencing method. In order to assess oxidative stress and apoptosis in men with -308G/A polymorphism, malondialdehyde and caspase-9 values were measured. The sperm DNA damage and sex chromosomes aneuploidy were also measured in these patients. Findings A significant higher frequency of A allele of -308G/A polymorphism was observed in men with oligoasthenospermia (P=0.01). In semen samples of the men with AA genotype, there was significantly high level of malondialdehyde and caspase-9 (P

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