Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats

authors:

avatar Najmeh Miraghaee 1 , avatar Abbas Sadeghi ORCID 2 , * , avatar Navid Mohammadi ORCID 3

Department of Sport Sciences, Allameh Qazvini Institute of Higher Education, Qazvin, Iran.
Department of Physical Education and Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran.
Children Growth Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Journal of Inflammatory Diseases: Vol.24, issue 5; 386-397
article type: issue_documents_importer

how to cite: Miraghaee N, Sadeghi A, Mohammadi N. Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats. J Inflamm Dis. 2020;24(5):e156239. 

Abstract

Background: One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases.  Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats.  Methods: In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05. Findings: The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591). Conclusion: he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.

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