The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs

nilofar Darbandi; Zeynab Vasheghani Farahani; Hamid Momeni

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

The Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs

Author(s):

nilofar Darbandi^1,*,

Zeynab Vasheghani Farahani¹,

Hamid Momeni²

1Department of Biology, Arak University, Arak, Iran

2Department of Biology, Faculty of Science, Arak University, Arak, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 1; 1-10

Article type:issue_documents_importer

How to Cite:nilofar DarbandiZeynab Vasheghani FarahaniHamid MomeniThe Effects of Pentoxifylline on Memory in Male Rats Treated with Zinc Oxide NPs.J Inflamm Dis.25(1):e156259.

Abstract

Background: Zinc oxide Nanoparticles (NPs) present irreversible effects on the nervous system, memory, and learning. Objective: The current study aimed to investigate the effects of pentoxifylline on memory impairments, CA1 hippocampal pyramidal cells, and blood serum antioxidant enzymes in male rats treated with zinc oxide NPs. Methods: Male Wistar rats were divided into the control, zinc oxide NPs (1.25 mg/kg), pentoxifylline (50 mg/kg), and pentoxifylline with zinc oxide NPs groups. In all study groups, saline, zinc oxide NPs, and pentoxifylline were intraperitoneally injected 30 minutes before training. In the co-treatment group, pentoxifylline was injected one hour before injecting Zno NPs. After performing the behavioral test, the tested animals’ brains were fixed and the number of healthy neurons in the CA1 region of the hippocampus was counted. In all research groups, malondialdehyde levels, total antioxidant power, superoxide dismutase levels, and glutathione peroxidase in blood serum were measured. Results: Zinc oxide nanoparticles decreased memory and the number of healthy neurons in the CA1 region of the hippocampus and increased oxidative stress in blood serum, compared to the controls. In the co-treatment group, using pentoxifylline improved the above-mentioned factors and reached the level of the control group. Pentoxifylline alone presented no significant effect on the aforementioned characteristics, compared to the control group. Conclusion: ZnO NPs may decrease memory retrieval and cause cell death in the pyramidal neurons of the CA1 region of the hippocampus by increasing oxidative stress. Pentoxifylline, as a potent antioxidant, can prevent the harmful effects of ZnO NPs.

Keywords

comments