Barriers to Receiving Tissue Plasminogen Activator in Patients with Ischemic Stroke

Monirsadat Mirzadeh; Hosein Mozhdehipanah; Ali Emami; Niloofar Motamed

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Barriers to Receiving Tissue Plasminogen Activator in Patients with Ischemic Stroke

Author(s):

Monirsadat Mirzadeh

¹,

Hosein Mozhdehipanah²,

Ali Emami

³,

Niloofar Motamed^4,*

1Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

2Department of Neurology, Bou-Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

3Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.

4Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 1; 11-18

Article type:issue_documents_importer

How to Cite:Monirsadat MirzadehHosein MozhdehipanahAli EmamiNiloofar MotamedBarriers to Receiving Tissue Plasminogen Activator in Patients with Ischemic Stroke.J Inflamm Dis.25(1):e156260.

Abstract

Background: Cerebrovascular diseases are the second common cause of mortality worldwide. The onset of reperfusion in the first 3-4.5 hours is a predictive factor of treatment. Objective: The present study investigated barriers to receiving tissue plasminogen activator in patients with ischemic stroke. Methods: This cross-sectional study examined 191 patients with first-ever stroke referring to the emergency department of the Persian Gulf Martyrs Hospital of Bushehr City, Iran, in 2016. One checklist was completed which included demographic data, history of diseases, knowledge of stroke symptoms, and intervals regarding the onset of symptoms to informing emergency, informing emergency on arrival at the emergency department of the hospital, and making the diagnosis for the patients. The obtained data were analyzed in SPSS v. 19. Results: Mean±SD age of the patients was 65.92±12.48 years. The majority of patients under investigation (55.5%) were female, 63.4% were married, 56% were illiterate and 72.3% resided in other districts of Bushehr province. Mean duration between onset of symptoms and arrival at emergency department, onset of symptoms and call the emergency service, time of arrival at emergency department to perform brain Computer Tomography (CT) scan and also to be counseled by a neurologist were 699.66, 195.51, 45.11 and 423.62 minutes, respectively. Finally 14.6 percent of patients were qualified to be treated with tPA. Conclusion: The main barrier to timely therapy is a delay in golden time. Therefore, public education to promote public awareness could be of great benefit in reducing the referral delay time.

Keywords

Stroke

Time

Health services accessibility

Therapeutics

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