The Effectiveness of Pilates Training and Vitamin D Intake on the hs-CRP and TSH in Overweight Men

authors:

avatar Fatemeh Ebrahemi Rokni 1 , avatar masoumeh habibian 1 , * , avatar Saqqa Farajtabar Behrestaq 1

Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran.
Journal of Inflammatory Diseases: Vol.25, issue 1; 31-38
article type: issue_documents_importer

How To Cite Ebrahemi Rokni F, habibian M, Farajtabar Behrestaq S. The Effectiveness of Pilates Training and Vitamin D Intake on the hs-CRP and TSH in Overweight Men. J Inflamm Dis. 2021;25(1):e156263. 

Abstract

Background: Vitamin D deficiency is known as a risk factor for various diseases and plays an important role in regulating systemic inflammation and thyroid function. Objective: The study was done to survey the effectiveness of Pilates training and vitamin D intake on serum high-sensitivity C-reactive protein (hs-CRP) and Thyroid-Stimulating Hormone (TSH) levels in overweight men. Methods: This clinical trial was conducted on 50 overweight men aged 45-55 years. Subjects were selected through available sampling and randomly assigned to the Pilates training, Pilates training with vitamin D, vitamin D, and control groups. The Pilates training was performed for eight weeks with the intensity of 50%-75% of reserve heart rate in 3 sessions/week. The supplement groups received 50000IU vitamin D weekly. The levels of hs-CRP and TSH were measured at first and eighth weeks after interventions. The data were analyzed by paired t-test and one-way ANOVA (P˂0.05). Findings: The results showed that 60% and 40% of the subjects had a vitamin D deficiency and insufficiency, respectively. Also, eight weeks of Pilates training, vitamin D intake, and the combined intervention resulted in a significant decrease in hs-CRP and TSH levels (P<0.05). Also, the combined intervention was associated with a stronger effect on the reduction of these factors compared with two other interventions (P˂0.05). Conclusion: It seems that abnormal levels of vitamin D are common in overweight men and vitamin D intake, Pilates training, and the combination can improve thyroid function and systemic inflammation in overweight men with abnormal vitamin D status. However, the combined intervention is associated with stronger effects

References

  • 1.

    Stpie M, Stpie A, Wlaze RN, Paradowski M, Banach M, Rysz J. Obesity indices and inflammatory markers in obese non-diabetic normol and hypertensive patients: A comparative pilot study. Lipids Health Dis. 2014; 13(1):29. [DOI:10.1186/1476-511X-13-29] [PMID] [PMCID].

  • 2.

    Mraovi T, Radakovi S, Medi DR, Dini D, Ostoji VT, airovi A, et al. The relationship between adiposity parameters and C-reactive protein values in overweight and obese women. Vojnosanit Pregl. 2018; 75(2):185-90. [DOI:10.2298/VSP160419208M].

  • 3.

    Kim D. The role of vitamin D in thyroid diseases. Int J Mol Sci. 2017; 18(1949):1-19. [DOI:10.3390/ijms18091949] [PMID][PMCID].

  • 4.

    Barchetta I, Baroni MG, Leonetti F, De Bernardinis M, Bertoccini L, Fontana M, et al. TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults. Clin Exp Med. 2015; 15(3):389-96. [DOI:10.1007/s10238-014-0290-9] [PMID].

  • 5.

    Gupta G, Sharma P, Kumar P, Gappa M, Sharma R. A Correlation between thyroid stimulating hormone and body mass index women with subclinical hypothyroidism. Asian J Pharm Clin Res. 2015; 8(4):206-8. https://innovareacademics.info/journals/index.php/ajpcr/article/download/6410/2717.

  • 6.

    Bansal A, Kaushik A, Singh CM, Sharma V, Singh H. The effect of regular physical exercise on the thyroid function of treated hypothyroid patients: An interventional study at a tertiary care center in Bastar region of India. Arch Med Health Sci. 2015; 3:244-6. [DOI:10.4103/2321-4848.171913].

  • 7.

    Mackawy AM, Al-Ayed BM, Al-Rashidi BM. Vitamin d deficiency and its association with thyroid disease. Int J Health Sci (Qassim). 2013; 7(3):267-75. [DOI:10.12816/0006054] [PMID][PMCID].

  • 8.

    Yarparvar A, Elmadfa I, Djazayery A, Abdollahi Z, Salehi F. The association of vitamin d status with lipid profile and inflammation biomarkers in healthy adolescents. Nutrients. 2020; 12(2):590. [DOI:10.3390/nu12020590] [PMID] [PMCID].

  • 9.

    de Oliveira C, Biddulph JP, Hirani V, Schneider IJC. Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA). J Nutr Sci. 2017; 6:e1. [DOI:10.1017/jns.2016.37] [PMID] [PMCID].

  • 10.

    Liefaard MC, Ligthart S, Vitezova A, Hofman A, Uitterlinden AG, Kiefte-de Jong JC, et al. Vitamin D and C-reactive protein: A mendelian randomization study PLoS One. 2015; 10(7):e0131740.[DOI:10.1371/journal.pone.0131740] [PMID] [PMCID].

  • 11.

    Lavanya K, Ramamoorthi K, Acharya RV, Madhyastha SP. Association between overweight, obesity in relation to serum hs-CRP levels in adults 20-70 years. J Clin Diagn Res. 2017; 11(12):OC32-35. [DOI:10.7860/JCDR/2017/32422.11005].

  • 12.

    Fedewa MV, Hathaway ED, Ward-Ritacco C. Effect of exercise training on C reactive protein: a systematic review and meta analysis of randomized and non-randomized controlled trials. BMJ. 2017; 51(8):10. [DOI:10.1136/bjsports-2016-095999] [PMID].

  • 13.

    Mehravar MR. The effect of eight-week Pilates exercise on the thyroid function in sedentary women. J Physic Act Horm 2018; 2(2):29-42. http://jpah.iaushiraz.ac.ir/article_542454_cf80ecc0574b3c3ad234989b123f7710.pdf.

  • 14.

    Onsori M, Galedari M. Effects of 12 weeks aerobic exercise on plasma level of TSH and thyroid hormones in sedentary women. Eur J Sport Sci Eur J Sport Sci. 2015; 4(1):45-9.https://www.researchgate.net/profile/Mohammad-Galedari-2/publication/319591512_.

  • 15.

    Solanki A, Bansal S, Jindal S, Saxena V, Shukla US. Relationship of serum thyroid stimulating hormone with body mass index in healthy adults. Indian J Endocrinol Metab. 2013; 17(Suppl 1):S167-9. [DOI:10.4103/2230-8210.119560][PMID] [PMCID].

  • 16.

    Manji N, Boelaert K, Sheppard MC, Holder RL, Gough SC, Franklyn JA. Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects. Clin Endocrinol. 2006; 64:125-8. [DOI:10.1111/j.1365-2265.2006.02433.x] [PMID].

  • 17.

    Chaudhary S, Dutta D, Kumar M, Saha S, Mondal SA, Kumar A, et al. Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial. Indian J Endocrinol Metab. 2016; 20:391-8. [DOI:10.4103/2230-8210.179997] [PMID] [PMCID].

  • 18.

    Khodadost M, Habibian M. Investigating the changes of tumor necrosis factor- and interleukin-10 after 8 weeks of regular pilates exercise and vitamin D intake in overweight men: A randomized clinical trial. J Arak Uni Med Sci. 2020; 23(6):888-901. [DOI:10.32598/jams.23.6.3537.5].

  • 19.

    Shaoba A, Basu S, Mantis S, Minutti C. Serum thyroidstimulating hormone levels and body mass index percentiles in children with primary hypothyroidism on levothyroxine replacement. J Clin Res Pediatr Endocrinol. 2017; 9(4):337-43. [DOI:10.4274/jcrpe.3661] [PMID] [PMCID].

  • 20.

    Sami A, Iftekhar MF, Rauf MA, Sher A. Subclinical Hypothyroidism among local adult obese population. Pak J Med Sci. 2018; 34(4):980-83. [DOI:10.12669/pjms.344.14127][PMID] [PMCID].

  • 21.

    Vyakaranam S, Kondaveedu S, Nori S, Dandge S, Bhongir AV. Study of serum high-sensitivity c-reactive protein in subclinical hypothyroidism. Indian J Med Biochem. 2018; 22(1):66-70. [DOI:10.5005/jp-journals-10054-0057].

  • 22.

    Zhang Q, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, et al. Association of high vitamin d status with low circulating thyroidstimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int J Endocrinol. 2014; 2014:631819. [DOI:10.1155/2014/631819] [PMID] [PMCID].

  • 23.

    Das G, Taylor PN, Javaid H, Tennant BP, Geen J, Aldridge A, et al. Seasonal variation of vitamin D and serum thyrotropin levels and its relationship in euthyroid cau casian population. Endocr Pract. 2018; 24(1):53-9. [DOI:10.4158/EP-2017-0058] [PMID].

  • 24.

    Talaei A, Ghorbani F, Asemi Z. The effects of vitamin D supplementation on thyroid function in hypothyroid patients: a randomized, double-blind, placebo-controlled trial. Indian J Endocrinol Metab. 2018; 22(5):584-88. [DOI:10.4103/ijem.IJEM_603_17] [PMID] [PMCID].

  • 25.

    Simsek Y, Cakir I, Yetmis M, Dizdar OS, Baspinar O, Gokay F. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci. 2016; 21:85. [DOI:10.4103/1735-1995.192501][PMID] [PMCID].

  • 26.

    Baharloo S, Taghian F, Hedayati M. [Effects of aerobic exercise on C-reactive protein and lipid profile in subclinical hypothyroidism among overweight-obese women (Persian)]. Modares J Med Sci (Pathobiology). 2014; 17(1):91-102. http://mjms.modares.ac.ir/article-30-718-en.html.

  • 27.

    Atashak S. The effect of eight weeks of Pilates training on C-reactive protein, insulin resistance, and body composition in middle-aged obese women. JRUMS. 2018; 17(5):421-34.http://journal.rums.ac.ir/article-1-3997-en.html.

  • 28.

    Seyfi E, Alijani M, Baghaiee B. [Investigating the effect of eight weeks of pilates training in combination with probiotic supplementation on some inflammatory markers in overweight women (Persian)]. Complement Med J Fac Nurs Midwifery. 2018; 8(1):2153-66.https://www.semanticscholar.org/paper/Investigating-the-Effect-of-Eight-Weeks-of-Pilates-AlijaniSeyfi/d9d4fa9c0c9b 013aba4099e19c2502079dfc88bc.

  • 29.

    Mala S, Kumar S, Piryanka K, Shaikh ZA. Serum inflammatory markers in subclinical hypothyroidism. Eur J Pharm Med Res. 2017; 4(9):855-9. https://www.researchgate.net/profile/Sateesh-Kumar-15/publication/338867857_.

  • 30.

    Kruit A, Zanen P. The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases. Clin Biochem. 2016; 49(7-8):534-7. [DOI:10.1016/j.clinbiochem.2016.01.002] [PMID]##.