The Effects of Oral Silver Nanoparticles and Propolis on the Level of Lipid Peroxidation in Male Wistar Rats

Hossein Piri; Sayyed Nima  Hashemi Ghermezi; Ehsan Aali; Seyed Amir Hadi Hosseini; Yazdan Naderi; Nematollah Gheibi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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The Effects of Oral Silver Nanoparticles and Propolis on the Level of Lipid Peroxidation in Male Wistar Rats

Author(s):

Hossein Piri¹,

Sayyed Nima Hashemi Ghermezi²,

Ehsan Aali³,

Seyed Amir Hadi Hosseini²,

Yazdan Naderi³,

Nematollah Gheibi

^4,*

1Department of Biochemistry and Genetics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

2Student Research Committee, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

3Department of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

4Cellular and Molecular Research Center, Research Institute for Prevention of Non-communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 2; 93-98

Article type:Research Article

How to Cite:Hossein PiriSayyed Nima Hashemi GhermeziEhsan AaliSeyed Amir Hadi HosseiniYazdan NaderiNematollah Gheibiet al.The Effects of Oral Silver Nanoparticles and Propolis on the Level of Lipid Peroxidation in Male Wistar Rats.J Inflamm Dis.25(2):e156281.

Abstract

Background: Oxidative stress is a leading factor in developing silver nanoparticle-induced toxicity. Objective: This study evaluated the effects of oral prescription of different doses of silver nanoparticles and propolis on lipid peroxidation in male Wistar rats. Methods: The male Wistar rats were randomly divided into four groups. Control group and three different treatment groups with oral prescription of 30 ppm, 60 ppm, and 60 ppm of silver nanoparticles with 200 mg/kg of propolis. The serum level of Malondialdehyde (MDA) was measured by Thiobarbituric Acid Reactive Substances (TBARS) assay using Thiobarbituric Acid (TBA). Results: The serum level of MDA as a marker of lipid peroxidation in the control group was 1.92 mM/mL, and in other groups that received silver nanoparticles (30 ppm, 60 ppm, 60 ppm with 200 mg/kg propolis) were respectively 2.82, 3.83 and 2.62 mM/mL. MDA level also increased at the doses of 30 ppm and 60 ppm compared to the control group and decreased when propolis was prescribed with silver nanoparticles in the third group; however, its value did not reach the level of the control group. Minimal levels of serum lipid peroxidation were observed when silver and propolis nanoparticles were administered to male rats. Conclusion: The mixture of silver nanoparticles and propolis reduces the toxic effects of silver nanoparticles; it preserves and increases the efficiency of this compound in medical applications.

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