Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women

authors:

avatar Reza Najafipour 1 , avatar Zahar Rashvand 1 , avatar Khadijeh Taherkhani 1 , avatar Solmaz Chamanara 2 , avatar Shokoh Abotorabi 2 , avatar Sahar Moghbelinejad 1 , *

Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.
Journal of Inflammatory Diseases: Vol.25, issue 3; 169-174
article type: issue_documents_importer

how to cite: Najafipour R, Rashvand Z, Taherkhani K, Chamanara S, Abotorabi S, et al. Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women. J Inflamm Dis. 2021;25(3):e156290. 

Abstract

Background: It has been reported that less than 5% of women experience recurrent pregnancy loss (RPL). different matrix metalloproteinases (MMPs) have proteolysis function with a main role in the stable development of the fetus. Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls. Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method. Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P<0.01) and A allele (OR:1.95, 95% CI:0.95-3.1, P<0.001) of rs11225395 G>A polymorphism in patients compared to controls. This high frequency was also reported in the haplotypes and combined genotypes of polymorphism. Conclusion: The MMP-8 gene may be involved in RPL risk and is a potential biomarker for RPL susceptibility.