Relationship Between Medication Adherence and Ankle-Brachial Index Value in Patients With Hypertension

authors:

avatar Simin Heidari 1 , * , avatar leili yekefallah ORCID 1 , avatar Azadeh Jalalpor 2 , avatar Mehdi Ranjbaran ORCID 3 , avatar Hamed Talakoob 4

Research Institute for Prevention of Non-communicable Diseases, School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran.
Metabolic Diseases Research Center, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Metabolic Diseases Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Journal of Inflammatory Diseases: Vol.25, issue 3; 175-182
article type: issue_documents_importer

how to cite: Heidari S, yekefallah L, Jalalpor A, Ranjbaran M, Talakoob H. Relationship Between Medication Adherence and Ankle-Brachial Index Value in Patients With Hypertension. J Inflamm Dis. 2021;25(3):e156291. 

Abstract

Background: Hypertension is one of the leading causes of death and physical disabilities. The ankle-brachial index (ABI) is one of the useful indicators of blood pressure with the ability to show the risk of peripheral artery disease. This study aims to investigate the relationship between medication adherence and the ABI lavue in patients with hypertension. Methods: In this descriptive cross-sectional study, 250 patients with hypertension referred to medical health centers in Karaj, Iran were enrolled using a convenience sampling method. To collect data, a demographic form and the 8-item morisky medication adherence scale (MMAS-8) were used. Also, the ABI was measured manually using an acoustic Doppler probe. Data were analyzed in SPSS software, v. 25. Findings: The Mean±SD of the right and left ABI were 1.055±0.134 and 1.036±0.113, respectively. The Mean±SD of MMAS-8 score was 5.88±1.74. It was found that 127 patients (50.8%) had low adherence level, 68 (27.2%) had moderate adherence level, and only 55 (22%) had high adherence level. There was a positive significant correlation between patients’ medication adherence and the ABI value. Moreover, a statistically significant difference was observed in the mean scores of the ABI in patients with three different levels of medication adherence. Conclusion: The medication adherence is poor among hypertensive patients in Karaj. It is related to the ABI such that with the decrease of medication adherence, the ABI value decreases. Therefore, adherence to medication regimen in patients with hypertension can be effective in preventing arterial complications.