Impact of Metabolic Syndrome in Patients With Acute Myocardial Infarction After Thrombolytic Therapy

Mohammad Mahdi Daei; Mohammad MahdiDaei; Samira Dodangeh; Majid Hajikarimi; Navid Mohammadi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

Impact of Metabolic Syndrome in Patients With Acute Myocardial Infarction After Thrombolytic Therapy

Author(s):

Mohammad Mahdi Daei¹,

Mohammad MahdiDaei²,

Samira Dodangeh²,

Majid Hajikarimi

^1,*,

Navid Mohammadi

³

1Clinical Research Development Unit, Bou-Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

2Children Growth Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

3Department of Social Medicine, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 4; 217-222

Article type:Research Article

How to Cite:Mohammad Mahdi DaeiMohammad MahdiDaeiSamira DodangehMajid HajikarimiNavid MohammadiImpact of Metabolic Syndrome in Patients With Acute Myocardial Infarction After Thrombolytic Therapy.J Inflamm Dis.25(4):e156297.

Abstract

Background: Metabolic syndrome (MetS) comprises a group of conditions that happen together and increase the risk of heart disorders. MetS has known characteristic diagnostic criteria and is diagnosed through physical examination and blood tests. This syndrome is extremely prevalent in patients with acute myocardial infarction. We aimed to determine the prevalence of MetS and its relationship with myocardial infarction and response to treatment in patients suffering from acute myocardial infarction under fibrinolytic treatment. Methods: In this cross-sectional study, 145 patients with acute ST-elevation myocardial infarction (STEMI) were enrolled. They were referred to Bu-Ali Sina Hospital in Qazvin, Iran, between January 2018 and January 2019 and were candidates for thrombolytic therapy. The patients were divided into two groups with and without MetS according to the NCEP ATP III definition (the National Cholesterol Education Program-Adult Treatment Panel III). In each group, the ST resolution of more than 50% in electrocardiogram was evaluated 90 minutes after thrombolytic administration. In addition, angiographic information and left ventricular ejection fraction (LVEF) were compared between the two groups. Results: Overall, the prevalence of MetS was 57.2% in the study population. After treatment, ST-segment resolution of more than 50%, the number of involved coronary vessels, the thrombolysis in myocardial infarction flow grade, mean LVEF, and type of myocardial infarction were similar in both study groups. Conclusion: Our study indicates that MetS does not affect the response rate to thrombolytic treatment.

Keywords

Metabolic syndrome

Thrombolytic drugs

Myocardial infarction

comments