Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran

Robabeh Faghany Baladehi; Ahad Bazmani; Mahin Ahangar Oskouee; Abolfazl Jafari Sales; Tahereh Pirzadeh; Behrouz Shokouhi; Mohammad Yousef Memar; Hossein Bannazadeh Baghi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran

Author(s):

Robabeh Faghany Baladehi^1,*,

Ahad Bazmani¹,

Mahin Ahangar Oskouee²,

Abolfazl Jafari Sales³,

Tahereh Pirzadeh⁴,

Behrouz Shokouhi⁵,

Mohammad Yousef Memar¹,

Hossein Bannazadeh Baghi¹

1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

2Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

3Department of Microbiology, School of Medical Sciences, Islamic Azad University, Kazerun, Iran.

4Department of Bacteriology, School of Medicine, Tabriz University of Medical, Sciences, Tabriz, Iran.

5Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Inflammatory Diseases:Vol. 26, issue 1; 19-26

Article type:Research Article

How to Cite:Robabeh Faghany BaladehiAhad BazmaniMahin Ahangar OskoueeAbolfazl Jafari SalesTahereh PirzadehBehrouz ShokouhiMohammad Yousef MemarHossein Bannazadeh Baghiet al.Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran.J Inflamm Dis.26(1):e156309.

Abstract

Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most common cancer diagnosis in men worldwide. Human papillomavirus (HPV) can potentially contribute to PCa development and chronic inflammation. HPV infection leads to malignant and benign lesions in the genital areas of men and women. The data on the role of HPV in PCa development is contradictory. Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran. Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method. Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years. Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.

Keywords

Prostate cancer (PCa)

Human papillomavirus (HPV)

HPV16

HPV18

Carcinoma

Benign prostatic hyperplasia (BPH)

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