The Effect of an Aqueous Extract of Illicium verum on Serum Levels of Thyroid Hormones and Depression, Anxiety, and Stress in Patients With Hypothyroidism

Yaghob Koushan; Ahmad Yari Khosroushahi; Mohammad Hossein Geranmayeh; Sima Hashemipour; Mahnaz Ghadimi Yari; Hossein Khadem

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

The Effect of an Aqueous Extract of Illicium verum on Serum Levels of Thyroid Hormones and Depression, Anxiety, and Stress in Patients With Hypothyroidism

Author(s):

Yaghob Koushan¹,

Ahmad Yari Khosroushahi²,

Mohammad Hossein Geranmayeh³,

Sima Hashemipour⁴,

Mahnaz Ghadimi Yari⁵,

Hossein Khadem^4,*

1Independent Researcher in Traditional Medicine, Tabriz, Iran.

2Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

4Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

5Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Journal of Inflammatory Diseases:Vol. 26, issue 3; 123-132

Article type:Research Article

How to Cite:Yaghob KoushanAhmad Yari KhosroushahiMohammad Hossein GeranmayehSima HashemipourMahnaz Ghadimi YariHossein Khademet al.The Effect of an Aqueous Extract of Illicium verum on Serum Levels of Thyroid Hormones and Depression, Anxiety, and Stress in Patients With Hypothyroidism.J Inflamm Dis.26(3):e156317.

Abstract

Background: Hypothyroidism has been associated with complications such as increased inflammation, and oxidative stress. Objective: This pilot study was created to assess the impact of Illicium verum (I. verum) on serum levels of thyroid hormones as well as depression, anxiety, and stress in hypothyroidism patients given the detrimental effects of oxidative stress on thyroid function and considering the antioxidant properties of I. verum. Methods: In this double-blind clinical research with a placebo group, which was performed as a pilot, 20 hypothyroid individuals were recruited. Participants were randomly allocated to a capsule containing 1.5 g of I. verum (per day) (n=10) or a placebo (n=10) for 8 weeks. Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured at the beginning and end of the study. Furthermore, depression and stress were assessed using the Depression Anxiety Stress Scales-21 (DASS-21) survey. Quantitative analysis was performed using SPSS software, version 20. Findings: No discernible difference was observed between the blood thyroid hormone levels at the baseline. TSH levels in the intervention group decreased significantly at the end of the study, while FT3, FT4, T3, and T4 levels increased significantly (P

Keywords

comments