Aging and Immunity in COVID-19

authors:

avatar Roberto Paganelli 1 , *

Department of Internal Medicine, Faculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences, Rome, Italy.

how to cite: Paganelli R. Aging and Immunity in COVID-19. J Inflamm Dis. 2022;26(3):e156321. 

Abstract

The COVID-18 pandemic severely affected people older than 65 years, especially those with age-related comorbidities, causing a disproportionate death burden in this age group. The reasons for this difference from other respiratory virus pandemics have been attributed to the aging-induced changes in the immune system, and their effects on the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. In this brief review, I summarize some of the recent findings throwing light on the relationship between aging, immunity, and the severity of COVID-19.