The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease

İlhan Kılıç; Elif Tuğba Oğuz Taylan; İlhan Kurultak; Sedat Üstündağ

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease

Author(s):

İlhan Kılıç^1,*,

Elif Tuğba Oğuz Taylan²,

İlhan Kurultak³,

Sedat Üstündağ⁴

1Department of Nephrology, Murat State Hospital, Edirne, Turkey

2Department of Internal Medicine, Murat State Hospital, Edirne, Turkey

3Department of Nephrology, School of Medicine, Trakya University, Edirne, Turkey.

4Department of Nephrology, School of Medicine, Trakya University, Edirne, Turkey

Journal of Inflammatory Diseases:Vol. 26, issue 4; e156334

Article type:Research Article

How to Cite:İlhan KılıçElif Tuğba Oğuz Taylanİlhan KurultakSedat ÜstündağThe Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease.J Inflamm Dis.26(4):e156334.

Abstract

Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients.
Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants.
Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001).
Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.

Keywords

C-reactive protein

Inflammation

Chronic kidney disease

End-stage renal disease

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