Keywords
The readmission of stroke patients remains a persistent issue, even with advancements in medical care, with reports indicating that the frequency of readmissions within the first year ranges from 31% to 56.1% (1). This high rate is a significant concern for both patients and healthcare providers, as the cycle of discharge followed by unplanned readmission not only impedes recovery but also places additional strain on the healthcare system. Although this issue has garnered attention from researchers, resulting in numerous quantitative and review studies, significant gaps remain in understanding how to effectively reduce stroke readmissions (2, 3). Some studies contain errors in estimating the odds ratios of risk factors, which complicates the application of their findings (4). Furthermore, efforts to develop reliable discharge planning for readmissions have largely been unsuccessful (5). The heterogeneity among studies regarding associated factors is notably high, with inconsistent findings related to age, gender, socioeconomic status, and comorbidities (2, 3). This variability underscores the need for more standardized research methodologies and comprehensive approaches to identify and address the multifaceted factors influencing stroke readmission rates.
Most studies are quantitatively designed and predominantly focus on clinical risk factors, such as cardiac diseases, renal diseases, infections, and comorbidities including hypertension, diabetes mellitus, and atrial fibrillation (5-10). Unfortunately, the social and cultural contexts of patients, such as their family support systems and community resources, as well as broader aspects of healthcare access and socioeconomic status, have not been adequately addressed in stroke recovery research. For instance, studies have shown that lower socioeconomic status and lack of social support significantly correlate with higher readmission rates (11, 12). As a result, the recommendations and discharge programs developed for these patients have often been impractical and ineffective, potentially explaining why 48% of patients fail to adhere to their discharge and treatment plans (13-15).
Much of the education provided to patients is confusing, vague, or impractical (16). This is because patient context and sociodemographic variables—such as education level, economic status, and insurance coverage—are frequently overlooked (17, 18). Without considering these factors, it is unrealistic to expect significant improvements in the readmission rates of stroke patients. Intervention programs, such as tailored rehabilitation services and personalized discharge planning, will only become more effective when all factors influencing stroke readmission, including patients' living conditions and access to follow-up care, are taken into account, and when these programs are customized to the specific sociodemographic characteristics of patients, such as age, ethnicity, and income level (19, 20).
To address the research gap in this field, it is crucial to incorporate qualitative studies that explore the lived experiences of stroke patients in their real-world contexts. Such studies can provide insights into the social determinants of health that contribute to readmission (21, 22). Additionally, recent studies have suggested policy strategies, such as implementing community-based support systems and enhancing patient education tailored to individual needs, which may help reduce readmission rates (23, 24).
While qualitative studies may have limitations, such as issues with generalizability, their results can be combined with quantitative findings to create comprehensive models or conceptual frameworks. These insights can guide the development of interventions and prevention programs aimed at reducing stroke-related readmissions, ultimately lowering morbidity, mortality, and associated healthcare costs.
References
-
1.
Morton JI, Ilomaki J, Wood SJ, Bell JS, Shaw JE, Magliano DJ. One-year readmission and mortality following ischaemic stroke by diabetes status, sex, and socioeconomic disadvantage: An analysis of 27,802 strokes from 2012 to 2017. J Neurol Sci. 2022;434:120149. [PubMed ID: 35065425]. https://doi.org/10.1016/j.jns.2022.120149.
-
2.
Deng Z, Wu X, Hu L, Li M, Zhou M, Zhao L, et al. Risk factors for 30-day readmission in patients with ischemic stroke: a systematic review and meta-analysis. Ann Palliat Med. 2021;10(10):11083-105. [PubMed ID: 34763470]. https://doi.org/10.21037/apm-21-2884.
-
3.
Zhong W, Geng N, Wang P, Li Z, Cao L. Prevalence, causes and risk factors of hospital readmissions after acute stroke and transient ischemic attack: a systematic review and meta-analysis. Neurol Sci. 2016;37(8):1195-202. [PubMed ID: 27129874]. https://doi.org/10.1007/s10072-016-2570-5.
-
4.
Rajabpour M, Mirhaghi A. A critical appraisal of "prevalence, causes, and risk factors of hospital readmissions after acute stroke and transient ischemic attack: a systematic review and meta-analysis". Neurol Sci. 2024;45(4):1763-4. [PubMed ID: 37987929]. https://doi.org/10.1007/s10072-023-07203-y.
-
5.
Lichtman JH, Leifheit-Limson EC, Jones SB, Watanabe E, Bernheim SM, Phipps MS, et al. Predictors of hospital readmission after stroke: a systematic review. Stroke. 2010;41(11):2525-33. [PubMed ID: 20930150]. [PubMed Central ID: PMC3021413]. https://doi.org/10.1161/STROKEAHA.110.599159.
-
6.
Kolmos M, Christoffersen L, Kruuse C. Recurrent Ischemic Stroke - A Systematic Review and Meta-Analysis. J Stroke Cerebrovasc Dis. 2021;30(8):105935. [PubMed ID: 34153594]. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105935.
-
7.
Mohan KM, Wolfe CD, Rudd AG, Heuschmann PU, Kolominsky-Rabas PL, Grieve AP. Risk and cumulative risk of stroke recurrence: a systematic review and meta-analysis. Stroke. 2011;42(5):1489-94. [PubMed ID: 21454819]. https://doi.org/10.1161/STROKEAHA.110.602615.
-
8.
Nikbakht H, Shojaie L, Niknejad N, Hassanipour S, Soleimanpour H, Heidari S, et al. Mortality Rate of Acute Stroke in Iran: A Systematic Review and Meta-Analysis. Caspian J Neurol Sci. 2022;8(4):252-67. https://doi.org/10.32598/cjns.4.31.338.1.
-
9.
Rao A, Barrow E, Vuik S, Darzi A, Aylin P. Systematic Review of Hospital Readmissions in Stroke Patients. Stroke Res Treat. 2016;2016:9325368. [PubMed ID: 27668120]. [PubMed Central ID: PMC5030407]. https://doi.org/10.1155/2016/9325368.
-
10.
Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol. 2011;11:110. [PubMed ID: 21933425]. [PubMed Central ID: PMC3185266]. https://doi.org/10.1186/1471-2377-11-110.
-
11.
Pantoja-Ruiz C, Akinyemi R, Lucumi-Cuesta DI, Youkee D, Emmett E, Soley-Bori M, et al. Socioeconomic Status and Stroke: A Review of the Latest Evidence on Inequalities and Their Drivers. Stroke. 2024. [PubMed ID: 39697175]. https://doi.org/10.1161/STROKEAHA.124.049474.
-
12.
Zumbrunn A, Bachmann N, Bayer-Oglesby L, Joerg R; Sihos Team. Social disparities in unplanned 30-day readmission rates after hospital discharge in patients with chronic health conditions: A retrospective cohort study using patient level hospital administrative data linked to the population census in Switzerland. PLoS One. 2022;17(9). e0273342. [PubMed ID: 36137092]. [PubMed Central ID: PMC9499293]. https://doi.org/10.1371/journal.pone.0273342.
-
13.
Cheiloudaki E, Alexopoulos EC. Adherence to Treatment in Stroke Patients. Int J Environ Res Public Health. 2019;16(2):196. [PubMed ID: 30641978]. [PubMed Central ID: PMC6351941]. https://doi.org/10.3390/ijerph16020196.
-
14.
Tascione O, Gardener H, Gutierrez C, Rose D, Rundek T, Jameson A, et al. Adherence to Blood Pressure Guidelines Predicts Hospital Readmission After Acute Stroke: The Florida Stroke Registry (S6.005). Neurol. 2022;98(18_supplement):3160. https://doi.org/10.1212/WNL.98.18_supplement.3160.
-
15.
Zhang J, Gong Y, Zhao Y, Jiang N, Wang J, Yin X. Post-stroke medication adherence and persistence rates: a meta-analysis of observational studies. J Neurol. 2021;268(6):2090-8. [PubMed ID: 31792672]. https://doi.org/10.1007/s00415-019-09660-y.
-
16.
Kharbach A, Obtel M, Achbani A, Bouchriti Y, Hassouni K, Lahlou L, et al. Level of Knowledge on Stroke and Associated Factors: A Cross-Sectional Study at Primary Health Care Centers in Morocco. Ann Glob Health. 2020;86(1):83. [PubMed ID: 32742941]. [PubMed Central ID: PMC7380055]. https://doi.org/10.5334/aogh.2885.
-
17.
Nindrea RD, Hasanuddin A. Non-modifiable and modifiable factors contributing to recurrent stroke: A systematic review and meta-analysis. Clin Epidemiol Glob Health. 2023;20. https://doi.org/10.1016/j.cegh.2023.101240.
-
18.
Zhou LW, Lansberg MG, de Havenon A. Rates and reasons for hospital readmission after acute ischemic stroke in a US population-based cohort. PLoS One. 2023;18(8). e0289640. [PubMed ID: 37535655]. [PubMed Central ID: PMC10399731]. https://doi.org/10.1371/journal.pone.0289640.
-
19.
Gonçalves-Bradley DC, Lannin NA, Clemson LM, Cameron ID, Shepperd S. Discharge planning from hospital. Cochrane Database Syst Rev. 2016;2016(1). CD000313. [PubMed ID: 26816297]. [PubMed Central ID: PMC7073416]. https://doi.org/10.1002/14651858.CD000313.pub5.
-
20.
Prick JCM, van Schaik SM, Deijle IA, Dahmen R, Brouwers P, Hilkens PHE, et al. Development of a patient decision aid for discharge planning of hospitalized patients with stroke. BMC Neurol. 2022;22(1):245. [PubMed ID: 35790912]. [PubMed Central ID: PMC9254531]. https://doi.org/10.1186/s12883-022-02679-1.
-
21.
Ang SY, Tin AS, Pavitar G, Ng WM, Lee KE, Lim LH, et al. A Qualitative Study into Stroke Caregivers' Educational Needs — Perspectives of Caregivers and Healthcare Professionals. Proc Singap Healthc. 2013;22(3):166-74. https://doi.org/10.1177/201010581302200303.
-
22.
Holloway I, Galvin K. Qualitative Research in Nursing and Healthcare. 4 ed. New Jersey, USA: Wiley; 2016.
-
23.
Finch E, Minchell E, Cameron A, Jaques K, Lethlean J, Shah D, et al. What do stroke survivors want in stroke education and information provision in Australia? Health Soc Care Community. 2022;30(6):e4864-72. [PubMed ID: 35768909]. [PubMed Central ID: PMC10084245]. https://doi.org/10.1111/hsc.13896.
-
24.
Magwood GS, Nichols M, Jenkins C, Logan A, Qanungo S, Zigbuo-Wenzler E, et al. Community-Based Interventions for Stroke Provided by Nurses and Community Health Workers: A Review of the Literature. J Neurosci Nurs. 2020;52(4):152-9. [PubMed ID: 32341258]. [PubMed Central ID: PMC7337158]. https://doi.org/10.1097/JNN.0000000000000512.