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Effects of Local Thermotherapy on Chest Pain in Patients with Acute Coronary Syndrome: A Clinical Trial


avatar Amin Moradkhani 1 , avatar Shahram Baraz ORCID 1 , * , avatar Habib Haybar 2 , avatar Akram Hemmatipour 3 , avatar Saeed Hesam ORCID 4

1 Nursing Care Research Center in Chronic Diseases, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Shoushtar University of Medical Sciences, Shoushtar, Iran

4 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Moradkhani A, Baraz S, Haybar H, Hemmatipour A, Hesam S. Effects of Local Thermotherapy on Chest Pain in Patients with Acute Coronary Syndrome: A Clinical Trial. Jundishapur J Chronic Dis Care. 2018;7(4):e69799.
doi: 10.5812/jjcdc.69799.


Jundishapur Journal of Chronic Disease Care: 7 (4); e69799
Published Online: December 11, 2018
Article Type: Research Article
Received: April 24, 2018
Revised: September 25, 2018
Accepted: October 15, 2018



The chest pain is a very common complaint among patients with acute coronary syndrome (ACS). The local thermotherapy can reduce or relieve the heart pain by suppressing metabolites as pain mediators.


This study aimed to determine the effect of local thermotherapy on the chest pain in patients with ACS.


This clinical trial was conducted on 78 patients with ACS hospitalized in the ICU of Golestan Hospital of Ahvaz in 2016. Based on the sample size and inclusion criteria, and by a convenience sampling, the eligible patients were enrolled and randomized into two equal-sized groups, namely control and intervention, each containing 39 participants. During the local thermotherapy sessions, the patients received local heat by using a hot pack warmed to 50°C for five days. The control group only received the routine treatment. Data collection instruments included a demographic questionnaire and the Numerical Rating Scale (NRS). The NRS was completed by the participants before the intervention and five days after it. Data were analyzed using the descriptive tests, correlation coefficient, independent t-test, Chi-square, and logistic regression in SPSS 20.


The mean pain severity in the case group before the intervention was 3.22 ± 0.86 and after the intervention, it decreased to 2.61 ± 0.7, indicating the effect of local thermotherapy. However, it was not statistically significant (P > 0.05). There was no significant relationship between age, gender, diabetes, hypertension, and hyperlipidemia, and the pain severity in this study (P > 0.05). Logistic regression analysis showed that women experienced more pain than men did.


This study suggested the slight effectiveness of local thermotherapy in reducing the severity of pain in these patients. As a result, further studies are recommended.

1. Background

A significant number of hospitalized patients at hospitals are patients with heart disease, especially patients with acute coronary syndrome (ACS) (1). The ACS is one of the manifestations of coronary artery disease, which results in the death of the cell as a result of the disparity between the intake of oxygen and the required oxygen due to reduced coronary blood flow (2, 3). Approximately, 1.1 million patients are admitted to hospitals each year in the United States for the diagnosis of ACS, of which more than one-third are women (3). The syndrome represents a range of early-onset deaths (30 days) ranging from one to 10% and recurrence rates of 5% - 15% during the first year (4-6). In Iran, the ACS is the most common cause of death, accounting for about 46% of the deaths (5).

The aim of pain treatment in patients with ACS is to restore myocardial blood flow, prevent or minimize cardiac damage, and prevent heart rate. However, increased blood pressure and the myocardium need for oxygen are some of the psychosocial problems of patients due to hospitalization (7-9).

Since the pain relief is the core of nursing care, the importance of playing this role by nurses who have a key role in pain management is more highlighted (10, 11). In addition, nurses spend time more than other medical staff with patients and they always decide on pain evaluation and management, specifically in ICUs (12).

Medicines such as morphine and non-pharmacological drugs are used to control the pain of coronary patients. Due to adverse drug reactions and differences in patient response, it is important that non-pharmacological methods along with analgesics be used to reduce pain and anxiety in patients because of their fewer complications and more access and effectiveness (7, 13).

Today, medical science tries to reduce medicine consumption or replace it by non-medicinal methods. This is because non-pharmacological techniques are associated with fewer side effects, and are more effective and accessible. Thermotherapy is a non-medicinal pain management technique, which can improve the signs and symptoms of these patients through different mechanisms (14).

Today, thermotherapy can act in two different ways for pain management: either on the surface tissues (skin) or in deep tissues (muscles) (15). Thermotherapy improves the symptoms by disposing the toxic metabolites, such as histamine and bradykinin, from the affected region, vasodilation, increasing blood flow to the inflamed and damaged area, and reducing sympathetic activity (14, 16). In a study, Nadler et al. showed the greater effectiveness of thermotherapy compared to ibuprofen and acetaminophen pills in relieving back pain (17).

There are several methods for delivering thermotherapy to the body, including hot packs. These packs are specifically heated pouches that in addition to delivery of heat and increase of blood flow in the region, allow the heat to penetrate into deeper tissues (18). In a study, Uchiyama-Tanaka showed that the application of hot packs in hemodialysis patients with acute cardiac disease reduced brain natriuretic peptide and normalized perfusion (19). In a study conducted by Mohammadian et al., the use of hot water pouch locally in the posterior part of the chest of patients with ACS was associated with decreased pain (5). Takayama et al. (20), Yildirim et al. (21), Yaghobi (18), Behmanesh (22), and Mohammadian (5) also reported the effectiveness of local thermotherapy in relieving pain in patients.

In contrast, Cui and Sinoway reported the negative effect of thermal stress on sympathetic nerves by increasing their activity in patients with chronic heart failure (23).

Regarding the condition of patients with ACS, the use of the sauna and thermotherapy in the acute stage of the disease is not possible (7). The symptoms may improve with local thermotherapy using hot packs, and the effects may be similar to the effects of a whole-body thermotherapy.

2. Objectives

Regarding the scant studies of local thermotherapy and its advantages (e.g. improvement of circulation, reduction of pain, improvement of physiological indices, universal accessibility, and ease of use), we aimed to determine the effect of local thermotherapy on the chest pain in patients with ACS hospitalized at Golestan Hospital in Ahvaz in 2015.

3. Methods

This clinical trial with code IRCT20161122031017N2 was registered in 2017. The statistical population included all patients with ACS hospitalized at the ICU of Ahvaz Golestan Hospital.

78 patients were selected using a purposive sampling strategy based on the difference between the means, the randomized complete block design with four factors, and inclusion criteria. The participants were then equally placed in the intervention or control groups.

The inclusion criteria were patients aged over 30-years-old, without addiction, without a history of psychological, muscle, and gastrointestinal problems, without a decreased level of consciousness, and without chest wound and scar.

The exclusion criteria were an unwillingness to participate and an incomplete questionnaire.

Data collection instruments included:

1. Demographic questionnaire (age, gender, history of diabetes, hypertension, and hyperlipidemia)

2. Numerical Rating Scale (NRS)

In the Numerical Rating Scale, patients were asked to rate their pain on a scale from 0 to 10, where 0 represents “no pain” and 10 represents the “worst possible pain.” The error rate of this scale is approximately 2%. The NRS is often used in studies of pain, e.g. by Sadoughi and Akkashe (24), and Jensen and Karoly (25). There is much evidence supporting the NRS validity for pain measurement, regardless of the type of pain and diversity of the population (24-26). Moreover, the content analysis was used to evaluate the scientific validity of the demographic questionnaire. To this end, the researcher prepared the initial questionnaire by deciding on the research items and conducting a literature review. Then, the opinions of 10 faculty members of the Nursing and Midwifery Faculty of Ahvaz University of Medical Sciences were obtained and used to introduce the required modifications for developing the final version of the questionnaire.

For observing the ethics of research, an ethical approval was obtained with the number of IR.AJUMS.REC.1396.144 from the University and a permission from the heads and officials of Ahvaz Golestan Hospital. After expressing the study objectives to the subjects, they were ensured that the confidentiality of their personal information would be maintained. The ethical principles of existing resources were also respected. The two groups received the routine care according to a cardiologist’s order.

In addition to the routine care, the intervention group received local thermotherapy with hot packs warmed to 50°C one hour after admission to the Heart Unit, following the administration of NRS. The 20-minute-length intervention was applied to the posterior chest by a nurse once a day. Thermotherapy was administered for five days, during which analgesics were given to patients in case of severe pain according to the specialist’s order. Before the intervention, the pain score was recorded in case of the occurrence of heart pain. In addition, the pain score was recorded during the intervention period (five days) until 12 hours after the last session.

The NRS was also administered to the control group immediately after the expression of pain before and after the routine care. It is worth noting that the hot pack temperature was adjusted to 50°C. Since studies have shown the uselessness of local thermotherapy at a temperature of lower than 45°C, which could be reached after 23 minutes, thermotherapy sessions in the current study lasted for 20 minutes (27).

The mean and standard deviation were used for describing quantitative variables, and frequency and percentage for qualitative ones. First, the relationship between each variable and the pain intensity variable was separately evaluated after the intervention. Then, variables with P < 0.2 were introduced to the multivariate model. Regarding the significant intergroup difference in the pain intensity before the intervention, the variables group therapy and pain intensity could not be included before the intervention. Therefore, the patients were categorized into two groups based on the mean pain intensity, and the univariate and multivariate analyses were conducted separately in these two subgroups. The independent t-test, paired t-test, Chi-square test, and Pearson correlation coefficient were used for univariate analysis and the multiple linear regression was used for multivariate analysis. All analyses were conducted in SPSS 20.

4. Results

76 patients were included in the study. The mean age of the intervention group was 57.59 ± 10.61 and 24 (61.5%) patients were male. Independent t-test before the intervention showed a significant difference in the mean pain severity between the intervention and control groups (P 0.001). However, there was no significant difference in the Chi-square test between the groups in terms of gender, diabetes mellitus, hypertension, and hyperlipidemia (P > 0.05) (Table 1).

Table 1. Frequency and Mean of Demographic Variables by Intervention and Control Groupsa
VariablesIntervention, N = 39Control, N = 39Significance Levelb
Male24 (61.5)19 (48.7)
Female15 (38.5)20 (51.3)
Yes20 (51.3)16 (41)
No19 (48.7)23 (59)
Blood pressure, mg/kg0.651
Yes21 (53.8)19 (48.7)
No18 (46.2)20 (51.3)
Hyperlipidemia, mg/kg0.224
Yes5 (12.8)6 (15.4)
No34 (87.2)33 (84.6)
Age, y57.59 ± 10.6154.97 ± 11.410.298
Pain intensity3.22 ± 0.864 ± 0.79< 0.001c

a Quantitative variables are presented as No. (%) and qualitative variables as mean ± SD.

b Based on chi-square and independent t-test.

c Significance level at P = 0.001.

This study showed that the mean pain scores in the intervention group were 3.22 ± 0.86 before the intervention and 2.61 ± 0.7 after it. In the control group, the mean pain scores were 4 ± 0.79 before the intervention and 3.05 ± 0.66 after it. The results indicated a significant difference in the pain score before and after the intervention (P < 0.001). According to Table 2, the intergroup comparison also showed a significant difference before the intervention (P < 0.001) and after the intervention P = 0.005).

Table 2. Comparison of the Mean Pain Score Before and After the Intervention by the Intervention and Control Groupsa
Groups Pain ScoreIntervention, N = 39Control, N = 39Significance Levelb
Before intervention4 ± 0.793.22 ± 0.86< 0.001c
After intervention3.05 ± 0.662.61 ± 0.70.005d
Significance level< 0.001d< 0.001d

a Values are expressed as mean ± SD.

b Based on paired t-test.

c Significance level at P = 0.001.

d Significance level at P = 0.05.

Using paired t-test, there was no significant difference between the two intervention and control groups before and after the intervention with respect to the median pain score of 3.6 (P > 0.05). However, the mean pain severity in each group alone with respect to the median of 3.6 was accompanied by a significant decrease in pain severity (P < 0.001) (Table 3).

Table 3. The Mean Pain Scores in the Intervention and Control Groups Before and After the Intervention by the Median Pain Score of 3.6a
GroupBefore InterventionAfter InterventionSignificance Levelb
Median pain score < 3.6
Control3.03 ± 0.282.41 ± 0.42< 0.001c
Intervention2.92 ± 0.662.36 ± 0.52< 0.001c
Significance level0.420.4751
Median pain score > 3.6
Control4.43 ± 0.513.33 ± 0.53< 0.001c
Intervention4.40 ± 0.413.57 ± 0.38< 0.001c
Significance level0.2420.882

a Values are expressed as mean ± SD.

b Based on paired t-test.

c Significance level at P = 0.001.

The Pearson correlation coefficient showed no significant relationship between the pain score and gender (P = 0.103), age (P = 0.422), high/low blood pressure (P = 0.476), diabetes (P = 0.470), and hyperlipidemia (P = 0.954). The application of the logistic regression to participants with the pain score of lower than 3.6 before the intervention showed that the post-intervention pain score was higher among women than among men, considering the research group as the control variable (P = 0.039). By considering gender as a control variable, there was no intergroup difference before and after the intervention (P = 0.906). By considering the research group as the control variable, there was no difference between men and women in terms of the post-intervention severity of pain among those with the pain score of higher than 3.6 before the intervention (P = 0.786). By considering gender as the control variable, there was no intergroup difference in terms of the severity of pain after the intervention (P = 0.906).

In subjects who had a pain severity score of more than 3.6 before the intervention, with control of the variables in the treatment groups, women and men had no significant difference in the pain severity after the intervention (P = 0.786). By controlling the variable gender, the two intervention and control groups did not differ in the pain severity after the intervention (P = 0.25).

5. Discussion

The results of the current study showed the effectiveness of local thermotherapy in reducing the severity of pain in patients with ACS; however, this reduction was not statistically significant. Regarding the intergroup difference in terms of the severity of pain before the intervention and considering a median pain score in this study, this difference was not significant either before or after the intervention. Nevertheless, the intragroup comparison indicated a significant reduction in the pain score after the intervention. In a study conducted by Haghighatian et al. although the severity of pain in patients with back pain was not significant before the intervention, the pain reduction was greater in the thermotherapy group than in the control group after the intervention (15). Moreover, Yildirim et al. showed the greater effectiveness of local thermotherapy, using hot packs, in reducing the severity of pain in patients with osteoarthritis compared to controls (21). Behmanesh et al. showed a greater reduction in the length of the third stage of labor and the severity of pain among women receiving local thermotherapy compared to a control group (22). Kuwahata et al. showed the effectiveness of sauna therapy in reducing the cardiac size and severity of pain in patients with heart failure (28). Mohammadian et al. also showed the effectiveness of thermotherapy in reducing the severity and frequency of pain in the case group that, in turn, reduced the need for opioid medications (5). French et al. showed that local thermotherapy reduced the severity of pain in patients with back pain after five days (29). Michlovitz et al. showed the greater effectiveness of local thermotherapy in relieving pain and reducing joint stiffness in patients with carpal tunnel syndrome (30). The results showed a consistency between the mentioned studies and the current study in terms of the intergroup difference in the severity of pain before the intervention; however, there was inconsistency in terms of thermotherapy effect after the intervention. The following may be the causes of this inconsistency: (I) Providing the control group with local thermotherapy by outsiders, such as family companions, beyond the research period, (II) inappropriate distribution of participants in the intervention and control groups, (III) not investigating the groups in terms of analgesic administration and its repetition, and (IV) differences in the place of hot pack application. Similar to the current study, the hot pack was placed on the posterior chest in the Mohammadian et al. study (5). On the other hand, Jiara, Omama, and Miamuto placed the hot pack on the anterior chest, which could not affect the heart rate (31-33). The effectiveness of local thermotherapy in improving pain in patients with ACS can be attributed to the improved myocardial perfusion as the main cause of pain is the reduced myocardial perfusion. In fact, pain mediators, such as bradykinin and histamine metabolites, are removed from the affected site, thereby preventing the occurrence of pain, providing relief, and reducing cardiac pain. Moreover, the stimulation of thermal receptors increases the endorphin secretion by the descending pain control system that, in turn, relieves the pain. On the other hand, it causes endothelial duplication and increased nitric oxide secretion, thereby improving myocardial perfusion that leads to pain reduction (14, 34). The current study did not show any significant relationship between the severity of pain and hyperlipidemia, low/high blood pressure, gender, age, and diabetes; whereas, Imamura et al. reported a reduction in glucose level, blood pressure, hyperlipidemia, and weight, as risk factors for atherosclerosis, through the repetition of thermotherapy for two consecutive weeks (31). This inconsistency with the current study may be due to the difference in the thermotherapy period, which was five days in this study versus two consecutive weeks in Imamura et al study, who reported a significant relationship between the severity of pain and the aforementioned factors after two weeks (31). Mohammadpur also reported a significant relationship between reduced blood pressure and the effect of local thermotherapy (7). Among the research limitations was the use of analgesics for pain management, which was out of the researcher’s control.

5.1. Conclusions

The application of local thermotherapy to the chest of patients with ACS was accompanied by the reduced severity of pain; however, this reduction was not significant. It is recommended to conduct more studies with a greater sample size and placement of hot pack on both anterior and posterior chest for pain reduction.



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