Study on the seroprevalence of hepatitis E virus infection in pregnant women referring to Imam Khomeini general hospital in Ahvaz

Mojtaba Rasti; Alireza Samarbafzadeh; Niloofar Neisi; Manoochehr Makvandi; Saeed Najafifard; Moosa Sharifat; Mahvash Zargar

Jentashapir Journal of Cellular and Molecular Biology

Official Journal of Ahvaz Jundishapur University of Medical Sciences

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Study on the seroprevalence of hepatitis E virus infection in pregnant women referring to Imam Khomeini general hospital in Ahvaz

Author(s):

Mojtaba Rasti¹,

Alireza Samarbafzadeh²,

Niloofar Neisi

^3,*,

Manoochehr Makvandi⁴,

Saeed Najafifard⁵,

Moosa Sharifat⁶,

Mahvash Zargar⁷

1M.Sc. of Virology, Health Research Institute, Infectious and Tropical Diseases Research Center, Department of Virology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

2Associated Professor of Virology, Health Research Institute, Infectious and Tropical Diseases Research Center, Department of Virology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

3Ph.D. Student of Virology, Health Research Institute, Infectious and Tropical Diseases Research Center and Research Institute for Infectious Diseases of Digestive System, Deptartment of Virology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

4Professor of Virology, Health Research Institute, Infectious and Tropical Diseases Research Center and Research Institute for Infectious Diseases of Digestive System, Deptartment of Virology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

5M.Sc. of Virology, Health Research Institute, Infectious and Tropical Diseases Research Center, Department of Virology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

6B.Sc. of Laboratory Sciences, Department of Pharmacology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

7Assistant Professor of Obstetrics and gynaecology, Department of Obstetrics and Gynaecology, Imam Khomeini Hospital, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Jentashapir Journal of Cellular and Molecular Biology:Vol. 5, issue 3; 101-105

Published online:May 13, 2013

Article type:Research Article

How to Cite:Mojtaba RastiAlireza SamarbafzadehNiloofar NeisiManoochehr MakvandiSaeed NajafifardMoosa SharifatMahvash Zargaret al.Study on the seroprevalence of hepatitis E virus infection in pregnant women referring to Imam Khomeini general hospital in Ahvaz.Jentashapir J Cell Mol Biol.5(3):101-105.

Abstract

Regarding to fecal- oral transmission of hepatitis E virus and risk of fulminant hepatitis in the third trimester of pregnancy, the aim of the present study was to determine seroprevalence of HEV in pregnant women with regard to age, level of education, trimester of pregnancy and residency.

A total of 418 serum samples were collected from January 2010 to January 2011. All pregnant women filled out the questionnaire form. Serum samples were examined for anti-HEV IgG and anti- HEV IgM using ELISA method.

From 418 women, 22 cases were positive for anti-HEV IgG (5.26%) and in one woman (0.23%) anti- HEV IgM was positive. In the age groups of 30-40 and 20-30 years, the seropositivity for anti-HEV IgG was 8.6% and 2.5%, respectively. In group with higher age the positive cases of anti-HEV IgG was higher than in the other group. The rate of positivity of anti-HEV IgG in pregnant women with low level of education was 11.4% whereas 3% in university educated women. There was a significant difference between seropositivity of anti-HEV IgG and the trimester of pregnancy. The most of anti-HEV IgG positive were occurred in the third trimester of pregnancy (8.6%).Out of this 22 anti-HEV IgG positive cases 4.4% were living in urban and 6.3% were in rural areas.

Regarding to fecal- oral transmission of hepatitis E virus and risk of fulminant hepatitis in the third trimester of pregnancy, the aim of the present study was to determine seroprevalence of HEV in pregnant women with regard to age, level of education, trimester of pregnancy and residency.

A total of 418 serum samples were collected from January 2010 to January 2011. All pregnant women filled out the questionnaire form. Serum samples were examined for anti-HEV IgG and anti- HEV IgM using ELISA method.

From 418 women, 22 cases were positive for anti-HEV IgG (5.26%) and in one woman (0.23%) anti- HEV IgM was positive. In the age groups of 30-40 and 20-30 years, the seropositivity for anti-HEV IgG was 8.6% and 2.5%, respectively. In group with higher age the positive cases of anti-HEV IgG was higher than in the other group. The rate of positivity of anti-HEV IgG in pregnant women with low level of education was 11.4% whereas 3% in university educated women. There was a significant difference between seropositivity of anti-HEV IgG and the trimester of pregnancy. The most of anti-HEV IgG positive were occurred in the third trimester of pregnancy (8.6%).Out of this 22 anti-HEV IgG positive cases 4.4% were living in urban and 6.3% were in rural areas.

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