Effect of Fumaria Parviflora hydro alcoholic extract on induced carageenan inflammation in male rat paw

Background:

This study investigated the anti-inflammatory effect of Fumaria Parviflora due to its Fumaric acid, flavonoid and phenolic compounds for skin diseases, relieves itching and eczema.

Material and methods:

Male wistar rats (ranging 150-180g in weight) were used. For preparation of the hydro alcoholic extract, Plant powdered were macerated in ethanol 70%, then extract were concentrated for further use. Five treatment Animal groups received dose of 200, 400, 600, 800 or 1000 mg/kg of Fumaria Parviflora extract, Positive control group received a dose of 300 mg/kg aspirin and negative control group received serum physiology solution with dose of 5 ml/kg via intra-peritoneal injection of traits. After half an hour, 100 micro liters of carageenan 1%was subcutaneously injected into the rats paw and then the volume of the rats paws were evaluated using PLethysmometer apparatus.once every hours between the first and fifth hours

Results:

200 and 400 mg/kg doses of extract had less effect on decreasing the paws edema in comparison with animal group received aspirin (p<0.05). However, dose of 600, 800 and 1000 mg/kg of the extract had more effects on decreasing the paws edema, but difference between two groups is not statistically significant (p>0.05).