Abstract
The animals were given 120 mg/kg (ip) of CIM . Control rats were received vehicle only.The animals were given CCl4 at doses of 0, 0.5,1, 1.5 or 2 mg/kg 12 h later. The rats were killed with over dose of sodium pentobarbital 24 h later. The blood was collected to determine of ALT, AST, ALP changes .The liver tissues were removed, fixed and processed to light microscopy, using H&E staining method.
The results of this study revealed that CCL4 had induced a dose- dependent injury in the liver of rat tissues. Statistical analysis showed a significant increase in all of biochemical parameters in CCl4-treated rats when compared to the control groups (P<0.05). The findings of this study also showed that CIM had no adverse effect on the rat liver and this agent protected cells against CCl4 toxicity.
The results of this study support the view that CIM has ability to reduce CCl4 induced hepatotoxicity. Our findings suggest that in the presence of CIM , parent form of CCl4 could induce more adverse effects than its toxic reactive metabolite(s).
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© 2010, Jundishapur Journal of Health Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.