Abstract
Introduction: It was to investigate bacterial lysates (BL)OM85-BV in pulmonary infection caused by Streptococcus pneumoniae(SP) in children.
Material and Method: 120 children with SP pulmonary infection were grouped: control group (Ctrl) and OM85-BV group (combined group, Com) at a 1:1 ratio. Mezlocillin 100 mL/kg/d was intravenously infused in the Ctrl, while based on the Ctrl, OM85-BV 3.5 mg/ time was orally administered in the Com. The improvement of clinical symptoms and pulmonary function indexes including respiratory rate (RR), tidal volume (TV), VPEF/VE, and TPEF/TE were compared. The levels of CRP, TNF-α, IL-6, soluble interleukin-2 receptor (sIL-2R), T lymphocyte subsets and immunoglobulin in serum were analyzed.
Result: As against the Ctrl, the Com had decreased RR, increased TV, VPEF/VE, and TPEF/TE, and decreased levels of serum inflammatory factors CRP, TNF-α, IL-6, and sIL-2R. As against the Ctrl, the Com had clearly increased serum T lymphocyte subsets CD3+, CD4+, CD4+/CD8+ and decreased CD8+, clearly increased serum IgA and IgG; The total effective rate (ER) of the Com was clearly superior as against the Ctrl (all P<0.05).
Conclusion: The addition of OM85-BV to SP pulmonary infection in children can clearly improve clinical symptoms, lung function, and immune function, inhibit inflammatory response and activation of TLRs/NF-κB pathway.
Keywords
TLRs/NF-κB pathway Pulmonary infection OM85-BV SP Mezlocillin
Copyright
© 2024, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.