article information

Jundishapur Journal of Microbiology: Vol.6, issue 7; e8495
published online: September 1, 2013
article type: Letter
received: October 9, 2012
revised: January 11, 2013
accepted: February 17, 2013
DOI: https://doi.org/10.5812/jjm.8495
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Comparison the Oral Candia Carriage in Type 2 Diabetic and Non Diabetics

authors:

avatar Abbas Ali Jafari 1 , avatar Elham Khanpayah 2 , avatar Hakimah Ahadian 3 , *

Medical Parasitology and mycology Department, Medical School, Shahid Sadoughi University of Medical Sciences,Yazd, IR Iran
Department of Orthodontics, Dentistry School, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
Department of Oral Medicine, Dentistry School, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran

how to cite: Jafari A A, Khanpayah E, Ahadian H. Comparison the Oral Candia Carriage in Type 2 Diabetic and Non Diabetics. Jundishapur J Microbiol. 2013;6(7):e8495. https://doi.org/10.5812/jjm.8495.

Dear Editor

Diabetes mellitus is a common and global epidemic in the new millennium, which is strongly related to lifestyle and economic change, caused chronic hyperglycemia with impairment of carbohydrate, lipid and protein metabolism resulting from defects in insulin secretion and action. The World Health Organization (WHO) has expected an increasing development of diabetes to more than 300 million by the year 2025; particularly, with type 2 diabetes mellitus (1). However, T2DM was known as an adult-onset of diabetes in the past, but it has dramatically increasing more recently in young people and known for about 90% of the global incidence of diabetes and its complications (2).

Candida infections, in particular, oral candidiasis has also been frequently recognized in diabetic patients, which can be due to their increased glucose in their oral fluids and their immune dysfunction (3, 4). Environmental alteration of diabetic oral cavity favors of Candida colonization and cause a change from the harmless commensally existence to a pathogenic state that known as predisposing factors for Candida infection. In this study, we compare the oral Candida carriage rate of 40 diabetic and 40 non diabetic by culture of their saliva samples and performing colony forming unit technique.

Our data showed a higher oral Candida carriage rate in type two diabetics in compare with the non-diabetic control group (Table 1). Spearman correlation test also showed statistically significant differences between the duration of diabetes and colonization of Candida albicans in their saliva (P = 0.0341), however there wasn’t seen any correlation between fasting blood-glucose level and oral Candia colonization in diabetic group (P = 0.512).

Table 1.

Oral Candida Carriage in Type 2 Diabetic and Non-Diabetic Subjects

SubjectsNo. of Cases With Oral Candida CarriageNo. of Cases Without Oral Candida CarriageTotal
Non-diabetic
Female5 (23.8)16 (76.2)21
Male4 (21.05)15 (78.95)19
Total9 (22.5)31 (77.5) 40
Type 2 Diabetic
Female11 (55)9 (45)20
Male13(65)7 (35)20
Total24 (60) 16 (40)40

Different oral Candida carriage rates were reported in most studies, which could be as a result of different sampling procedures (such as, whole saliva collection, swabs, water and buffer rinsing and etc) used by different investigators. The whole saliva sample collection and colony forming unit (CFU) technique used in present study is a sensitive technique, which is usually used for estimating the oral Candida carriage and also for clinical diagnosis of oral candidiasis (3, 4). Current study has affirmed that Candida colonization is more prevalent in the oral cavity of type 2 diabetics than non-diabetics subjects as reported by various studies (5-7). There wasn't seen any association between FBS level and oral Candida colonization in type 2 diabetics saliva however Khosravi et al. reported a significant relationship between oral yeast density of diabetic patients and their fasting blood glucose level (8). A higher colonization of Candida in diabetics with longer history of diabetes was seen (P = 0.0341), which supported by few other similar studies (5, 9, 10). Results of present study indicated a higher oral Candida carriage in type 2 diabetics and recommended more attention for controlling of diabetes.

Acknowledgements

References

  • 1.

    Diabetes--a global threat. Lancet. 2009;373(9677):1735. [PubMed ID: 19465209]. https://doi.org/10.1016/S0140-6736(09)60954-5.

  • 2.

    WHO Technical Report Series. Prevention of diabetes mellitus. Geneva: WHO Publications; 1994.

  • 3.

    Sahin I, Oksuz S, Sencan I, Gulcan A, Karabay O, Gulcan E, et al. Prevalance and risk factors for yeast colonization in adult diabetic patients. Ethiop Med J. 2005;43(2):103-9. [PubMed ID: 16370540].

  • 4.

    Samaranayake LP, MacFarlane TW. Host factors and oral candidosis. Oral candidosis. 1990:66-103.

  • 5.

    Bai KY, Reddy CD, Abu-Talib SH. Oral candidal carriage in young insulin dependent diabetics. J Indian Soc Pedod Prev Dent. 1995;13(1):20-3. [PubMed ID: 9522735].

  • 6.

    Kumar BV, Padshetty NS, Bai KY, Rao MS. Prevalence of Candida in the oral cavity of diabetic subjects. J Assoc Physicians India. 2005;53:599-602. [PubMed ID: 16190127].

  • 7.

    Willis AM, Coulter WA, Fulton CR, Hayes JR, Bell PM, Lamey PJ. Oral candidal carriage and infection in insulin-treated diabetic patients. Diabet Med. 1999;16(8):675-9. [PubMed ID: 10477213].

  • 8.

    Khosravi AR, Yarahmadi S, Baiat M, Shokri H, Pourkabireh M. Factors affecting the prevalence of yeasts in the oral cavity of patients with diabetes mellitus. J Med Mycol. 2008;18(2):83-88.

  • 9.

    Lotfi-Kamran MH, Jafari AA, Falah-Tafti A, Tavakoli E, Falahzadeh MH. Candida Colonization on the Denture of Diabetic and Non-diabetic Patients. Dent Res J (Isfahan). 2009;6(1):23-7. [PubMed ID: 21528026].

  • 10.

    Tekeli A, Dolapci I, Emral R, Cesur S. Candida carriage and Candida dubliniensis in oropharyngeal samples of type-1 diabetes mellitus patients. Mycoses. 2004;47(7):315-8. [PubMed ID: 15310337]. https://doi.org/10.1111/j.1439-0507.2004.00996.x.