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Study of bacteria isolated from urinary tract infections and determination of their susceptibility to antibiotics

AUTHORS

avatar Mansour Amin 1 , * , avatar Manijeh Mehdinejad 2 , avatar Zohreh Pourdangchi 2

1 Department of Medical Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, [email protected], Iran

2 Department of Medical Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran

How to Cite: Amin M, Mehdinejad M, Pourdangchi Z. Study of bacteria isolated from urinary tract infections and determination of their susceptibility to antibiotics. Jundishapur J Microbiol.2(3): 118-123.

ARTICLE INFORMATION

Jundishapur Journal of Microbiology: 2 (3); 118-123
Article Type: Research Article
Received: June 1, 2009
Accepted: September 1, 2009
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Abstract

Introduction and objective: Approximately 1 in 3 women will require antimicrobial treatment for a Urinary Tract Infection (UTI) before age 24, and 40% to 50% of women will have a UTI during their lifetime. UTIs in male patients are considered complicated. Escherichia coli is the most common cause of UTIs.

Materials and methods: In the present study 7056 patients with clinical symptoms and suspected to UTI were sampled. Clean-Catch midstream urine of the patients was collected. Urine specimens were cultured for isolation of the microbial agents of UTI. The isolated bacteria were identified using biochemical tests. Disk diffusion susceptibility test was used to determine susceptibility of bacterial agents to antibiotics.

Results: In this study 553(8.7%) patients out of 7056 were shown to be urine culture positive (68% females and 32% males). The most isolated bacterium was E. coli with frequency rate of 59%. The other bacteria were Klebsiella spp. (11.6%), Enterobacter spp. (9.8%), Pseudomonas spp. (7.2 %), Proteus spp. (2.9%), Acinetobacter spp. (2.7%), Congolese positive Staphylococci (2.2%), Coagolase negative Staphylococci (2.3%), Citrobacter spp. (1.3%) and Streptococci α hemolytic (1.1%). All Gram-negative bacteria were more sensitive to amikacin (90.5-100%). The Gram-positive cocci isolated were more sensitive to tobramycin, kanamycin and ciprofloxacin (100%).  

Conclusion: It is concluded that Gram-negative bacilli were responsible for UTI infections in our patients. The most common isolated bacteria from urinary tract infections were E. coli and the most effective antimicrobial agents were amikacin, tobramicin and ciprofleoxacin against Gram-negative bacilli and also the most effective antibiotics against Gram-positive cocci were kanamicin, tobramicin and ciprofleoxacin.

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