https://doi.org/10.5812/jjm.3521

The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study)

authors:

avatar Mohsen Khorrami 1 , avatar Saeid Tabatabaei 2 , * , avatar Mirabbas Ahmadarabi 3

Razi Hospital, Trauma Research Center Jundishapur University of Medical Sciences, IR Iran
Razi Hospital, Trauma Research Center Jundishapur University of Medical Sciences, Saaidt1379@hotmail.com, IR Iran
Orthopedic Surgeon, Boroujerd, IR Iran
Jundishapur Journal of Microbiology: Vol.5, issue 2; 427-429
article type: Research Article
received: June 1, 2011
accepted: November 25, 2011

how to cite: Khorrami M, Tabatabaei S, Ahmadarabi M. The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study). Jundishapur J Microbiol. 2012;5(2): 427-429. https://doi.org/10.5812/jjm.3521.

Abstract

Background: Antibiotic therapy prevents postoperative infections after orthopedic procedures, but the method and prescribed dose of this therapy are debated. Short-term prophylaxis and long-term prophylaxis are 2 accepted methods after orthopedic procedures.
Objectives: In this prospective observational study, we compared the results of short-term and long-term prophylaxis after elective orthopedic procedures at 2 hospitals of Jundishapur University of Medical Sciences.
Patients and Methods: We divided patients who underwent uneventful orthopedic operations into 2 groups, administered short- and long-term prophylactic antibiotic therapy, respectively, and observed the patients for signs and symptoms of superficial and deep infections. We compared and analyzed the results with SPSS, considering P values of less than 0.001 to indicate a significant difference.
Results: There was no significant difference regarding superficial and deep infections between short- and long-term prophylaxis groups; thus, both methods can be used for prophylaxis after elective orthopedic surgeries, effecting equal rates of success.
Conclusions: Short-term prophylaxis can be used for clean orthopedic procedures with equivalent results as long-term therapy.

  • Implication for health policy/practice/research/medical education:
    In using short-term antibiotic prophylaxis in clean orthopedic procedures we can avoid side effects and also it is more cost-effective.
  • Please cite this paper as:
    Khorrami M; Tabatabaei S, Ahmadarabi M. The Efficacy of Short-Term vs. Long-Term Antibiotic Therapy in Preventing Deep Infection After Orthopedic Procedures (A Prospective Observational Study). Jundishapur J Microbiol.2012;5(2):427-9. DOI: 10.5812/jjm.3521

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