article information

Jundishapur Journal of Natural Pharmaceutical Products: Vol.8, issue 1; 10-14
published online: February 13, 2013
article type: Research Article
received: July 25, 2012
accepted: October 20, 2012
DOI: https://doi.org/10.17795/jjnpp-7404
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Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

authors:

avatar Ardeshir Arzi 1 , avatar Behnam Ghorbanzadeh 2 , * , avatar Zahra Nazari Khorasgani 2

Department of Pharmacology and Toxicology, School of Pharmacy, Physiology Research Center, Jundishapur University of Medical Sciences, IR Iran
Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, b_ghorbanzadeh82@yahoo.com, IR Iran

how to cite: Arzi A, Ghorbanzadeh B, Nazari Khorasgani Z. Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats. Jundishapur J Nat Pharm Prod. 2013;8(1): 10-14. https://doi.org/10.17795/jjnpp-7404.

Abstract

Background:

Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain.

Objectives:

To investigate the antinociceptive activity of Iranian green tea extract.

Materials and Methods:

The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection.

Results:

The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1.

Conclusions:

These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.

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