Abstract
Background: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.
Materials and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under- went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.
Result: P53 marker was positive in 40 cases (%74). Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlated with vascular and neural invasion or involvement of margins (p≥0.05).
Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua- tion of p53 level could be a useful tool in identification of patients with more aggressive disease.
Materials and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under- went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.
Result: P53 marker was positive in 40 cases (%74). Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlated with vascular and neural invasion or involvement of margins (p≥0.05).
Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua- tion of p53 level could be a useful tool in identification of patients with more aggressive disease.
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Copyright
© 2015, Jundishapur Journal of Oncology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.