Evaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer

1Assistant Professor of Pathology, Department of Pathology, Imam Khomeini Hospital , School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2MD, Resident of Pathology, Department of Pathology, Imam Khomeini Hospital, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jundishapur Journal of Oncology:Vol. 1, issue 1; 5-8

Published online:Mar 20, 2015

Article type:Research Article

How to Cite:Nastaran RanjbariNeda HojatpanahEvaluation of correlation between the expression of p53 as a immunohistochemical marker&prognosis of gastric cancer.1(1):e148099.https://doi.org/10.22118/jjo.2015.49182.

Abstract

Background: Gastric cancer is the most common form of gastro intestinal malignancy in certain part of the word and the most common type is Adenocarcinoma. The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression. Therefore in this study, we investigate p53 expression in gastric cancer specimens and possible relationship between this marker and clinical-pathological factors of disease.
Materials and methods: This study included 54 patients with primary Adenocarcinoma of stomach whom under- went gastrectomy at the Ahvazs Emam Khomeini hospital. Tumor specimens examined by immuno-histochemical staining with monoclonal antibody against p53. For evaluate value of p53, A stain was considered positive, when %20 of cancer cells showed a positive nuclear staining.
Result: P53 marker was positive in 40 cases (%74). Stronger expression of p53 was related with higher grade (p=0/035) and lymph node metastasis (p=0/033). No significant differences were seen between value of p53 marker with age, sex, tumor size, depth of invasion and tumor type. Expression of p53 was not correlated with vascular and neural invasion or involvement of margins (p≥0.05).
Conclusion: In gastric cancer, the expression of p53provides significant information about prognosis and evalua- tion of p53 level could be a useful tool in identification of patients with more aggressive disease.

Keywords

p53

Adenocarcinoma

Immunohistochemical staining

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Author(s):

Nastaran Ranjbari:[PubMed][Scholar]
Neda Hojatpanah:[PubMed][Scholar]