Neoadjuvant Chemotherapy in Local Advanced Gastric Cancer

1Associate Professor of Surgery, Surgical Oncologist, Cancer, Environmental and Petroleum Pollutants Research Center Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2General surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Assistant Professor of Radiotherapy and Oncology, Department of Radiotherapy and Oncology, Golestan Hospital, Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jundishapur Journal of Oncology:Vol. 1, issue 1; 21-24

Published online:Mar 20, 2015

Article type:Research Article

How to Cite:Abdolhassan TalaiezadehAmir Jafar ModirgolestanHodjatollah ShahbazianNeoadjuvant Chemotherapy in Local Advanced Gastric Cancer.Jundishapur J Oncol.1(1):e148103.https://doi.org/10.22118/jjo.2015.49185.

Abstract

Background: Gastric cancer remains a major cause of cancer death in Iran despite a significant decreasing inci-dence in western countries. Surgery alone has not been effective for treatment of locoregional gastric cancer be-cause of the low rate of curative resection and high incidence of local recurrence and distant metastases. Our aim was to determine the resectability of tumor after neoadjuvant chemotherapy.

Material and Methods: Fourteen patients with clinical stage III gastric adenocarcinoma that initially seemed to be unresectable by laparoscopy were treated with three cycles of cisplatin 60 mg/m2, 5-Fluorouracil 750 mg/m2 and Epirubicin 50 mg/m2 three weeks before surgery.

Results: Thirteen patients were operable for surgery after neoadjuvant chemotherapy (Pvalue= 0.001), while one patient was not operable due to developing distal metastasis. Twelve (85.85%) patients were resectable with patho-logic report of R 0 and, one (7.15%) patient was reported R1, (Pvalue= 0.001). A total number of 97 patients, with mediastinal involvement by primary masses, were contributed in this study. Biopsy was taken through the several ways. The numbers of 52(53.60%) “Lymphoma” and 45 (46.40%) cases with other pathologic results were dominantly detected with “tuberculosis”. Two cases of lymphoma was found in two referred cases with MMs <10 years and the overall incidence of involvement was begun from first to fifth dec-ades with the peak in third to fourth decades along with mostly anterior mediastinal locations.

Conclusion: This study shows that neoadjuvant chemotherapy improves operability and resectability of the tumor in patients with local advanced gastric adenocarcinoma.

Keywords

Gastric adenocarcinoma

Neoadjuvant chemotherapy

local advanced

Resectability

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Author(s):

Abdolhassan Talaiezadeh:[PubMed][Scholar]
Amir Jafar Modirgolestan:[PubMed][Scholar]
Hodjatollah Shahbazian:[PubMed][Scholar]