Frequency of histological subtypes and patients’ survival with tumors originating from thymus

authors:

avatar Seyed Mohammad Hosseini 1 , * , avatar Ali Reza Nezami 2 , avatar Puya Nezami 3 , avatar Sasan Razmjoo 1 , avatar Sholeh Arvandi 1 , avatar Hodjatollah Shahbazian 1

Department of Radiotherapy and Oncology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Tehran University of Medical Sciences, Tehran, Iran

how to cite: Hosseini S M, Nezami A R, Nezami P, Razmjoo S, Arvandi S, et al. Frequency of histological subtypes and patients’ survival with tumors originating from thymus. Jundishapur J Oncol. 2015;1(2):e148178. https://doi.org/10.22118/jjo.2015.49188.

Abstract

Background: Thymoma is a rare tumor in the mediastinum. Due to the fact that a complete study has not been conducted on thymoma in Khuzestan region, this study was designed as part of a comprehensive study on thymoma in Ahvaz Golestan Hospital.
Materials and Methods: This retrospective study was conducted on patients’ medical records with Thymoma attending Department of Radiotherapy and Oncology, Ahvaz Golestan Hospital, in a 10-year period from 2001 to 2011. The study also aimed to investigate the epidemiological data; diagnosis and treatment of patients for the duration of the same time.
Results: Among the 26 patients with a mean age of 45.38±SE, ratio of male to female was 5.5 to 1. The majority of the patients were in the range of 30-50 years old which jointly was at 61.8±SE. However, the minimum rate of tumor was seen in decades of 51-60 and 71-80 (7.7 %). In total, 72.7% (n=19) patients had invasive thymoma, while 27.3% (n=8) had
noninvasive tumor. In addition, there was a significant relationship between invasive thymoma rate and developing
myasthenia gravis. The 3-year survival rate for all patients was equivalent to 83.3%. However; 5-year survival was equal to 71%.
Conclusion: According to the study, most patients with invasive thymoma had a 5-year survival rate and also most of them were with myasthenia gravis.