Abstract
Background: There is some evidence that neoadjuvant chemoradiation for stages II and III rectal tumors associated with significant greater rate of complete pathologic response and sphincter preservation. The aim of this study was to determine the outcome of neoadjuvant chemoradiation in patients with advanced rectal cancer.
Materials and Methods: In this retrospective investigation, the medical records of all patients with stage II or III that underwent neoadjuvant chemoradiation (during 2005-2010) were studied. Radiotherapy was delivered by 4500-5000cGy/25-28f for 25-28 sessions, and oral 5-FU and weekly injected Eloxatin were administered. Then, all patients underwent surgery by one expert oncologist surgeon. Data include demographic data, the kind of operation, the rate of pathologic complete response and clear surgical margins and sphincter preservation were collected. Data were analyzed with SPSS software version 14.
Results: Among70 patients, the mean age was 46±13 years and 71.5% of them were male.Ten percent had the pathologic complete response, 60% had clear surgical margins. Sphincter preservation rate in cases which the distance of the tumor from anal verge was five cm or more and in cases which it was less than five cm were 51.4% and 5.6%, respectively.
Conclusion: Our results indicated that neoadjuvant chemoradiation recommended for patients with the stages II and III rectal cancers. The advantages of this modality are relatively higher chance of complete response and anal sphincter saving procedure.
Materials and Methods: In this retrospective investigation, the medical records of all patients with stage II or III that underwent neoadjuvant chemoradiation (during 2005-2010) were studied. Radiotherapy was delivered by 4500-5000cGy/25-28f for 25-28 sessions, and oral 5-FU and weekly injected Eloxatin were administered. Then, all patients underwent surgery by one expert oncologist surgeon. Data include demographic data, the kind of operation, the rate of pathologic complete response and clear surgical margins and sphincter preservation were collected. Data were analyzed with SPSS software version 14.
Results: Among70 patients, the mean age was 46±13 years and 71.5% of them were male.Ten percent had the pathologic complete response, 60% had clear surgical margins. Sphincter preservation rate in cases which the distance of the tumor from anal verge was five cm or more and in cases which it was less than five cm were 51.4% and 5.6%, respectively.
Conclusion: Our results indicated that neoadjuvant chemoradiation recommended for patients with the stages II and III rectal cancers. The advantages of this modality are relatively higher chance of complete response and anal sphincter saving procedure.
Keywords
Neoadjuvant chemoradiation rectal cancer sphincter saving procedure TME
Copyright
© 2016, Jundishapur Journal of Oncology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.