The Association Between H. pylori Antibodies as a Risk of Gastric Cancer and Vitamin D Levels

authors:

avatar Mehrdad Haghighi 1 , avatar Amir Mohammad Alborzi 2 , avatar Reza Ghanbari 3 , *

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, Iran
Jundishapur Journal of Oncology: Vol.2, issue 2; 38-44
published online: December 01, 2016
article type: Research Article
received: September 13, 2016
accepted: October 11, 2016
DOI: https://doi.org/10.32598/jjo.20.2.3

how to cite: Haghighi M, Alborzi A M, Ghanbari R. The Association Between H. pylori Antibodies as a Risk of Gastric Cancer and Vitamin D Levels. Jundishapur J Oncol. 2016;2(2):e148192. https://doi.org/10.32598/jjo.20.2.3.

Abstract

Objectives: Helicobacter pylori (H. pylori) infection is a significant cause of chronic gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most showed the effect of serum levels of 25 hydroxy vitamin D (25[OH]D) on the eradication of H. pylori infection. In the present study, we aimed to assess the association between vitamin D serum levels and various types of antibodies against H. pylori infection. It is well recognized that H. pylori infection is the most important risk factor for gastric adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor prognosis in gastric cancer.
Methods: In the present laboratory-based retrospective study, the medical records of random individuals referred for screening to the Negaresh Pathobiology Laboratory in Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects were eligible for evaluation and were enrolled. The serum concentration of Vitamin D was determined quantitatively via a fully automated enzyme-linked immunosorbent assay (ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined. In conclusion, no significant relationship was identified between the level of vitamin D and the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.