Abstract
Objectives: Helicobacter pylori (H. pylori) infection is a significant cause of chronic gastritis. Various studies have reported a link between H. pylori and vitamin D levels. Most showed the effect of serum levels of 25 hydroxy vitamin D (25[OH]D) on the eradication of H. pylori infection. In the present study, we aimed to assess the association between vitamin D serum levels and various types of antibodies against H. pylori infection. It is well recognized that H. pylori infection is the most important risk factor for gastric adenocarcinoma. Furthermore, vitamin D deficiency may be associated with a poor prognosis in gastric cancer.
Methods: In the present laboratory-based retrospective study, the medical records of random individuals referred for screening to the Negaresh Pathobiology Laboratory in Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects were eligible for evaluation and were enrolled. The serum concentration of Vitamin D was determined quantitatively via a fully automated enzyme-linked immunosorbent assay (ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined. In conclusion, no significant relationship was identified between the level of vitamin D and the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.
Methods: In the present laboratory-based retrospective study, the medical records of random individuals referred for screening to the Negaresh Pathobiology Laboratory in Tehran, Iran, from 2019 to 2021 were retrospectively reviewed. A total of 196 subjects were eligible for evaluation and were enrolled. The serum concentration of Vitamin D was determined quantitatively via a fully automated enzyme-linked immunosorbent assay (ELISA), and H. pylori IgG, IgM, and IgA antibodies were analyzed quantitatively by using the ELISA microplate reader.
Results: According to our results, the serum levels of 25(OH)D did not change significantly in different groups of patients with different levels of H. pylori IgG, IgM, and IgA antibodies.
Discussion: The relationship between vitamin D and H. pylori remains to be determined. In conclusion, no significant relationship was identified between the level of vitamin D and the amount of different anti-H pylori antibodies, including IgG, IgM, and IgA.
Keywords
Anti-Helicobacter pylori antibody Helicobacter pylori Vitamin D
Copyright
© 2016, Jundishapur Journal of Oncology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.