Abstract
Introduction: Cardiac arrhythmia is one of the most common types of heart diseases, which is a main cause of mortality. Drugs used to treat the cardiac arrhythmia are called antiarrhythmic drugs. Drugs such as amiodarone, can induce some of the side effects. Antioxidant agents play an important protective role in cardiovascular diseases. Therefore, medicinal herb with antioxidant properties is regarded as an alternative to chemical drugs. Salvia officinalis is an evergreen perennial shrub commonly seen all over the Mediterranean and south-eastern Europe regions. The aim of this study was to evaluate the electrophysiology and antiarrhythmic properties of Sage (Salvia officinalis L.) on CaCl2 - induced arrhythmias in rats.
Materials and Methods: Forty male Sprague-dawley rats (200-250 g) were divided into 5 groups: control (N/S, 1 ml/kg, gavage, 28 days), hydroalcoholic extract of all part of Sage (100, 150, 200 mg/kg, gavage, 28 days), and amiodarone (10 mg/kg). Lead II electrocardiogram was recorded for calculating HR and voltage of QRS complex. The arrhythmia was produced by i.v. injection of a solution CaCl2 (140 mg/kg). Percentages of Ventricular arrhythmias (tachycardia, fibrillation and premature beats) were recorded. Results were analyzed using one-way ANOVA, t-test and Fisher's exact test.
Results: Results showed positive inotropic and negative chronotropic effects in all groups in comparison with the control group. Administration of Salvia officinalis showed that incidence of Ventricular premature beat, Ventricular tachycardia and Ventricular fibrillation were significantly reduced compared to amiodarone group.
Conclusions: The results suggest a protective role of Salvia officinalis against cardiac diseases. This effect may have to do with the antioxidant properties of phenolic compounds in Sage.
Materials and Methods: Forty male Sprague-dawley rats (200-250 g) were divided into 5 groups: control (N/S, 1 ml/kg, gavage, 28 days), hydroalcoholic extract of all part of Sage (100, 150, 200 mg/kg, gavage, 28 days), and amiodarone (10 mg/kg). Lead II electrocardiogram was recorded for calculating HR and voltage of QRS complex. The arrhythmia was produced by i.v. injection of a solution CaCl2 (140 mg/kg). Percentages of Ventricular arrhythmias (tachycardia, fibrillation and premature beats) were recorded. Results were analyzed using one-way ANOVA, t-test and Fisher's exact test.
Results: Results showed positive inotropic and negative chronotropic effects in all groups in comparison with the control group. Administration of Salvia officinalis showed that incidence of Ventricular premature beat, Ventricular tachycardia and Ventricular fibrillation were significantly reduced compared to amiodarone group.
Conclusions: The results suggest a protective role of Salvia officinalis against cardiac diseases. This effect may have to do with the antioxidant properties of phenolic compounds in Sage.
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Copyright
© 2018, Jundishapur Journal of Physiology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.