A Comparison of Chronotropic and Dromotropic Properties of Vanillic Acid and Exercise in Aged and Young Rats

Mahin Dianat; Maryam Radan; Mohammad Badavi; Alireza Sarkaki

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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A Comparison of Chronotropic and Dromotropic Properties of Vanillic Acid and Exercise in Aged and Young Rats

Author(s):

Mahin Dianat¹,

Maryam Radan^1,*,

Mohammad Badavi¹,

Alireza Sarkaki¹

1Department of Physiology, Persian Gulf Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jundishapur Journal of Physiology:Vol. 1, issue 1; 6-11

Published online:Oct 20, 2018

Article type:Research Article

Received:Jan 20, 2018

Accepted:Sep 15, 2018

How to Cite:Mahin DianatMaryam RadanMohammad BadaviAlireza SarkakiA Comparison of Chronotropic and Dromotropic Properties of Vanillic Acid and Exercise in Aged and Young Rats.Jundishapur J Physiol.1(1):e148262.

Abstract

Introduction: Cardiovascular disease represents the proportion of the global burden of disease. Age is by far the most important risk factor in developing cardiovascular or heart diseases, with approximately a tripling of risk with each decade of life. The aim of this study is to compare the effects of exercise and vanillic acid (VA) on heart rate and P-R interval (cardiac health indexes) in aged and young rats.
Materials and Methods: Sixty four male Sprague - Dawley rats were divided into 8 groups. Young and aged: control, VA (10 mg/kg, gavage, 10 days), exercise (1 h, at speed 17 m/min, six times per week) and exercise + VA. Lead II electrocardiogram was recorded by Bio Amp and monitored by a Power Lab system. Heart rate (as chronotropic property) and P-R interval (as dromotropic property) were calculated from ECG recording. ANOVA was used for statistical analysis and P<0.05 was considered as significant level.
Results: The results presented in this study demonstrated that heart rate did not change with aging, although there was a significant P-R interval prolongation in aged groups. However, exercise and administration of VA displayed negative chronotropic (with the highest activity in young groups) and dromotropic properties as compared to controls. In the studied groups, physical activity and administration of VA had a heart rate reduction and a P-R interval prolongation effect in aged and young rats.
Conclusions: The results suggest that VA and exercise have a protective role in preventing and treating irregular heartbeats.

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