Abstract
Introduction: Cardiovascular disease represents the proportion of the global burden of disease. Age is by far the most important risk factor in developing cardiovascular or heart diseases, with approximately a tripling of risk with each decade of life. The aim of this study is to compare the effects of exercise and vanillic acid (VA) on heart rate and P-R interval (cardiac health indexes) in aged and young rats.
Materials and Methods: Sixty four male Sprague - Dawley rats were divided into 8 groups. Young and aged: control, VA (10 mg/kg, gavage, 10 days), exercise (1 h, at speed 17 m/min, six times per week) and exercise + VA. Lead II electrocardiogram was recorded by Bio Amp and monitored by a Power Lab system. Heart rate (as chronotropic property) and P-R interval (as dromotropic property) were calculated from ECG recording. ANOVA was used for statistical analysis and P<0.05 was considered as significant level.
Results: The results presented in this study demonstrated that heart rate did not change with aging, although there was a significant P-R interval prolongation in aged groups. However, exercise and administration of VA displayed negative chronotropic (with the highest activity in young groups) and dromotropic properties as compared to controls. In the studied groups, physical activity and administration of VA had a heart rate reduction and a P-R interval prolongation effect in aged and young rats.
Conclusions: The results suggest that VA and exercise have a protective role in preventing and treating irregular heartbeats.
Materials and Methods: Sixty four male Sprague - Dawley rats were divided into 8 groups. Young and aged: control, VA (10 mg/kg, gavage, 10 days), exercise (1 h, at speed 17 m/min, six times per week) and exercise + VA. Lead II electrocardiogram was recorded by Bio Amp and monitored by a Power Lab system. Heart rate (as chronotropic property) and P-R interval (as dromotropic property) were calculated from ECG recording. ANOVA was used for statistical analysis and P<0.05 was considered as significant level.
Results: The results presented in this study demonstrated that heart rate did not change with aging, although there was a significant P-R interval prolongation in aged groups. However, exercise and administration of VA displayed negative chronotropic (with the highest activity in young groups) and dromotropic properties as compared to controls. In the studied groups, physical activity and administration of VA had a heart rate reduction and a P-R interval prolongation effect in aged and young rats.
Conclusions: The results suggest that VA and exercise have a protective role in preventing and treating irregular heartbeats.
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Copyright
© 2018, Jundishapur Journal of Physiology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.