Ellagic acid enhances the anti-nociceptive effects of cyclooxygenase inhibitors in a mouse visceral pain model

Masumeh Abbasi; Mohammad Taghi Mansouri; Bahareh Naghizadeh; Behnam Ghorbanzadeh

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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Ellagic acid enhances the anti-nociceptive effects of cyclooxygenase inhibitors in a mouse visceral pain model

Author(s):

Masumeh Abbasi¹,

Mohammad Taghi Mansouri^{2, 3,*},

Bahareh Naghizadeh⁴,

Behnam Ghorbanzadeh⁵

1School of Medicine, Arvand Branch, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2Department of Pharmacology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Neuroanesthesia Laboratory, Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA

4Department of Pharmacology, School of Pharmacy, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

5Department of Pharmacology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran

Jundishapur Journal of Physiology:Vol. 1, issue 1; 22-28

Published online:Oct 20, 2018

Article type:Research Article

Received:Mar 15, 2018

Accepted:Sep 20, 2018

How to Cite:Masumeh AbbasiMohammad Taghi MansouriBahareh NaghizadehBehnam GhorbanzadehEllagic acid enhances the anti-nociceptive effects of cyclooxygenase inhibitors in a mouse visceral pain model.Jundishapur J Physiol.1(1):e148265.

Abstract

Introduction: Combination therapies have long been used to treat painful conditions while reducing side effects. Recently, we have reported the central and peripheral antinociceptive effects of ellagic acid (a polyphenol compound in pomegranates, grapes and different berries). The present study aimed to evaluate the therapeutic potential of combination treatment with ellagic acid (EA) and nonsteroidal anti-inflammatory drugs (NSAIDs) in a visceral model of pain.
Materials and Methods: The abdominal writhing test was selected as a model of visceral inflammatory pain. Different doses of EA, indomethacin, celecoxib and acetaminophen alone or in combination with EA were administered.
Results: Data showed that EA at doses 1–10 mg/kg i.p. significantly reduced the writhes’ number induced by acetic acid in mice. Moreover, intraperitoneal administration of indomethacin at 3, 10 mg/kg, celecoxib at 10, 30 mg/kg, and acetaminophen at 200, 300 mg/kg, significantly reduced the writhing reaction. On the other hand, combination of sub-effective dose of EA (0.3 mg/kg; i.p.) with sub-analgesic doses of indomethacin (0.3, 1 mg/kg; i.p.), celecoxib (1, 3 mg/kg; i.p.) and acetaminophen (60, 100 mg/kg; i.p.) significantly decreased the number of writhes as compared to the per se effect.
Conclusions: These results indicate that EA markedly potentiates the antinociceptive activity of NSAIDs in visceral pain model. Further, these results suggest that the described combination therapies would be effective as an alternative to conventional NSAIDs and may lower incidence of their adverse effects.

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