Abstract
Introduction: Diabetes Mellitus, Type II, is a public health problem which has reached epidemic proportions due to the rapidly increasing rates of this disease worldwide. More than 246 million people in the world have diabetes. Pharmaceutical and non-pharmaceutical strategies for control and treatment of diabetes was provided. Exercise and nutrition, including non-drug strategies for the prevention and control of diabetes are considered.
Materials and Methods: This was a quasi-experimental study. 24 men with type 2 diabetes were selected and randomly divided in four groups (1. control, 2. saffron extract, 3. aerobic exercise, 4.aerobic exercise and saffron extract). Saffron extract was used in amount of 3 mg/kg/BW per daily. Aerobic exercise, three days a week, for eight weeks, with 55-70% of maximum heart rate were performed. At the end, levels of HbA1c and Apolipoprotein A-1 were measured. Data were analyzed by one-way ANOVA and Tukey tests.
Results: Aerobic training (p=0.33), saffron extract (p=0.26) and saffron combined with Aerobic training (p=0.48) was no significant decrease effect on HbA1c levels in diabetic men. But in all three groups, a significant decrease in the amount of Apo A-1, in diabetic men, was observed (p <0.05).
Conclusions: Apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. Aerobic exercise and saffron extract can increased levels of Apo A-1 in men with type 2 diabetes.
Materials and Methods: This was a quasi-experimental study. 24 men with type 2 diabetes were selected and randomly divided in four groups (1. control, 2. saffron extract, 3. aerobic exercise, 4.aerobic exercise and saffron extract). Saffron extract was used in amount of 3 mg/kg/BW per daily. Aerobic exercise, three days a week, for eight weeks, with 55-70% of maximum heart rate were performed. At the end, levels of HbA1c and Apolipoprotein A-1 were measured. Data were analyzed by one-way ANOVA and Tukey tests.
Results: Aerobic training (p=0.33), saffron extract (p=0.26) and saffron combined with Aerobic training (p=0.48) was no significant decrease effect on HbA1c levels in diabetic men. But in all three groups, a significant decrease in the amount of Apo A-1, in diabetic men, was observed (p <0.05).
Conclusions: Apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. Aerobic exercise and saffron extract can increased levels of Apo A-1 in men with type 2 diabetes.
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Copyright
© 2018, Jundishapur Journal of Physiology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.