Abstract
Medicinal plants have been identified and used as primary sources in prevention and treatment of diseases from ancient times due to its various pharmacological activities. In this review, the inhibitory effects of extracts, some fractions and some constituents of medicinal plants on histamine (H1) receptors were reviewed. Various databases including; Medline, PubMed, Science Direct, Scopus, and Google Scholar were searched using inhibitory effect, histamine (H1) receptor, medicinal plants and their constituent’s keywords from 1974 to 2016. All studied plants including; Nigella sativa, Rosa damascena, Thymus vulgaris, Carum copticom, Zataria multiflora, Crocus sativus, Portulaca oleraceae, Bunium persicum, Satureja hortensis, Ephedra sinica, Humulus lupulus, Combretum racemosum, Aegle marmelos, Ginkgo biloba and Eriobotrya japonica showed a competitive antagonism effect on histamine (H1) receptors. Therefore, the studied plants and their constituents could be of therapeutic values in clinical practice as antihistamines drugs.
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© 2018, Jundishapur Journal of Physiology. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.