Antidiabetic Effects of Teucrium polium and Achillea millefolium aqueous extracts on Streptozotocin-Induced Diabetic Rats

Ali Reza Mir; Mohammad Reza Shahraki; Gholam Reza Komeli

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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Antidiabetic Effects of Teucrium polium and Achillea millefolium aqueous extracts on Streptozotocin-Induced Diabetic Rats

Author(s):

Ali Reza Mir^1,*,

Mohammad Reza Shahraki¹,

Gholam Reza Komeli¹

1Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran

Jundishapur Journal of Physiology:Vol. 1, issue 2; 60-68

Published online:Oct 20, 2018

Article type:Research Article

Received:Mar 01, 2018

Accepted:Sep 25, 2018

How to Cite:Ali Reza MirMohammad Reza ShahrakiGholam Reza KomeliAntidiabetic Effects of Teucrium polium and Achillea millefolium aqueous extracts on Streptozotocin-Induced Diabetic Rats.Jundishapur J Physiol.1(2):e148605.

Abstract

Introduction: Recently, the search for appropriate hypoglycemic agents has focused on plants. This study evaluated the antidiabetic Effects of Teucrium polium and Achillea millefolium aqueous extracts in diabetes.
Materials and Methods: Fifty adult male Wistar rats were randomly divided into fiveGroups: normal rats (A); Diabetic control (B); Diabetic rats were treated with Achillea millefolium extract (C); Diabetic rats were treated with Teucrium polium extract (D); Diabetic rats were treated with Teucrium polium and Achillea millefolium mixture extracts (E). Diabetes was induced by a single dose (55 mg/kg, ip) of streptozotocin. Rats in groups C, D and E received the Achillea millefolium, Teucrium polium and mixture extracts, respectively by gavages. The control diabetic rats (B) received the same volume of normal saline and the control healthy rats (A) received normal chow and tap water. Finally, animals were anesthetized, sacrificed and blood samples were collected from the cervical vein. The biochemical parameters were measured by ordinary methods.
Results: Our results showed that FBS, total cholesterol, triglyceride, and LDL, GGT, food and water intake decreased significantly in groups C, D and E while body weight and HDL increased significantly in these groups when compared to the diabetic control group. The activity of serum ALP decreased significantly in groups C and E while there were no significant diferences of ALT and AST between groups C, D and E compared to the diabetic control group (P<0.05).
Conclusions: The results demonstrated that extracts of Teucrium polium and Achillea millefolium have antidiabetic effects.

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