The effect of parents' diabetes on memory and learning in Rats' Offspring'

Alireza Sarkaki; Shiva Ahmadian; Mohammad Badavi; Yaghoob Farbood

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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The effect of parents' diabetes on memory and learning in Rats' Offspring'

Author(s):

Alireza Sarkaki^1,*,

Shiva Ahmadian²,

Mohammad Badavi¹,

Yaghoob Farbood¹

1Department of Physiology, Persian Gulf Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2Department of Biology, Sciences Faculty, Islamic Azad University, Kazeroon Branch, Kazeroon ,Iran

Jundishapur Journal of Physiology:Vol. 1, issue 2; 69-75

Published online:Oct 20, 2018

Article type:Research Article

Received:Jun 04, 2018

Accepted:Sep 26, 2018

How to Cite:Alireza SarkakiShiva AhmadianMohammad BadaviYaghoob FarboodThe effect of parents' diabetes on memory and learning in Rats' Offspring'.Jundishapur J Physiol.1(2):e148606.

Abstract

Introduction: Parental diabetes may influence risk factors in the offspring and are difficult to identify without accurate dates of diagnosis. The Aim of this study was to evaluate the effect of paternal and maternal diabetes type 1 on spatial learning and memory of adult male and female rats’ offspring.
Materials and Methods: Wistar adult male and female rats were divided randomly in control (healthy) and diabetic groups. In order to mate 5 females+3 males were placed in each cage and grouped as following: 1) NMNF (normal males coupled with normal femals), 2) NMDF (normal males coupled with diabetic females), 3) DMNF (Diabetic males coupled with normal females), and 4) DMDF (both males and females were diabetic and coupled). In order to make the animal model of diabetes healthy male and female rats received a single dose of sterptozotocin (STZ, 60 mg/kg, i.p.) and their blood glucose higher than 250 mg/dl recorded as diabetic state 5 days after STZ injection. Adult offspring (both sexes separately, at least 85-90 days old) were tested in Morris water maze (MWM) for spatial learning and memory 4 trials daily for 4 consecutive days and followed by a single trial as probe (memory test) 24 h later.
Results: Spatial learning of male offspring with paternal or maternal diabetes alone was impaired while it did not in female offspring (with except for swimming speed). In other hand memory of both sexes’ offspring with one or both diabetic parents was improved significantly.
Conclusions: It may be concluded; that offspring obtained from diabetic parents (one or both of them) have a risk for cognitional behavior in adult life at least at an early age. However, little is known about the precise biological process behind these effects in later life.

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