Abstract
Materials and Methods: Wistar adult male and female rats were divided randomly in control (healthy) and diabetic groups. In order to mate 5 females+3 males were placed in each cage and grouped as following: 1) NMNF (normal males coupled with normal femals), 2) NMDF (normal males coupled with diabetic females), 3) DMNF (Diabetic males coupled with normal females), and 4) DMDF (both males and females were diabetic and coupled). In order to make the animal model of diabetes healthy male and female rats received a single dose of sterptozotocin (STZ, 60 mg/kg, i.p.) and their blood glucose higher than 250 mg/dl recorded as diabetic state 5 days after STZ injection. Adult offspring (both sexes separately, at least 85-90 days old) were tested in Morris water maze (MWM) for spatial learning and memory 4 trials daily for 4 consecutive days and followed by a single trial as probe (memory test) 24 h later.
Results: Spatial learning of male offspring with paternal or maternal diabetes alone was impaired while it did not in female offspring (with except for swimming speed). In other hand memory of both sexes’ offspring with one or both diabetic parents was improved significantly.
Conclusions: It may be concluded; that offspring obtained from diabetic parents (one or both of them) have a risk for cognitional behavior in adult life at least at an early age. However, little is known about the precise biological process behind these effects in later life.
Keywords
Parental diabetes offspring spatial cognition Morris water maze Rat