The role of QX-314 and Capsaicin in producing long-lasting local anesthesia in the animal model of Trigeminal Neuralgia

Masoumeh Ezzati Givi; Narges Ezzati Givi; Hadi Imani Rastabi; Farzin Memari

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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The role of QX-314 and Capsaicin in producing long-lasting local anesthesia in the animal model of Trigeminal Neuralgia

Author(s):

Masoumeh Ezzati Givi^1,*,

Narges Ezzati Givi²,

Hadi Imani Rastabi³,

Farzin Memari⁴

1Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2Department of Periodontology, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

4Dentist, Ahvaz, Iran

Jundishapur Journal of Physiology:Vol. 2, issue 1; 1-5

Published online:May 22, 2021

Article type:Research Article

Received:Feb 14, 2021

Accepted:Mar 07, 2021

How to Cite:Ezzati Givi M, Ezzati Givi N, Imani Rastabi H, Memari F, The role of QX-314 and Capsaicin in producing long-lasting local anesthesia in the animal model of Trigeminal Neuralgia.Jundishapur J Physiol.2021;2(1):e148608.

Abstract

Introduction: Trigeminal Neuralgia (TN) consists of painful attacks often triggered with general activities, which cause impairment and disability.
The first line of treatment consists of pharmacotherapy. However, the occurrence of many side-effects limits its application. Acute pain relief is
crucial for titrating oral drugs and making time for neurosurgical intervention. This study aimed to examine the long-term anesthetic effect of QX-
314 and capsaicin in trigeminal neuralgia using an animal model.
Materials and Methods: TN was stimulated by surgical constriction of the infraorbital nerve in rats. After seven days, anesthesia infiltration
was done, and the duration of mechanical allodynia was compared. Thirty-five male Wistar rats were randomly divided into seven groups as
follows: control (normal saline); lidocaine (2%); QX314 (30 mM); lidocaine (2%)+QX314 (15 mM); lidocaine (2%)+QX314 (22 mM); lidocaine
(2%)+QX314 (30 mM); and lidocaine (2%)+QX314 (30 mM) +capsaicin (1μg).
Results: QX314 in combination with lidocaine significantly increased the duration of anesthesia, which was dose-dependent. The combination of
lidocaine+QX314+capsaicin could significantly increase the duration of anesthesia in trigeminal neuralgia.
Conclusion: In the present study, we demonstrated that the combination of QX-314 with lidocaine and capsaicin produced a long-lasting, reversible
local anesthesia and was superior to lidocaine alone in the fields of the duration of trigeminal neuropathic pain blockage.

Keywords

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