A Review on the Effective Properties of Crocin in the Management of Cardiopulmonary Dysfunction

Mahin Dianat; Maryam Radan

Jundishapur Journal of Physiology

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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A Review on the Effective Properties of Crocin in the Management of Cardiopulmonary Dysfunction

Author(s):

Mahin Dianat¹,

Maryam Radan^1,*

1Department of Physiology, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jundishapur Journal of Physiology:Vol. 2, issue 1; 22-28

Published online:May 22, 2021

Article type:Research Article

Received:Oct 11, 2021

Accepted:Dec 11, 2021

How to Cite:Dianat M, Radan M, A Review on the Effective Properties of Crocin in the Management of Cardiopulmonary Dysfunction.Jundishapur J Physiol.2021;2(1):e148725.

Abstract

Background: Cardiopulmonary disorders are defined as a wide range of conditions that affect the heart and respiratory system. Cardiovascular Disease (CVD) and Chronic Obstructive Pulmonary Disorder (COPD) are the leading causes of early death worldwide. Oxidative stress reflects an imbalance between the Reactive Oxygen Species (ROS) and the buffering capacity of the antioxidant defense system, which ultimately causes molecular abnormalities and cellular damage. Natural antioxidants can protect biological systems against these toxic mediators. Crocin, as the main saffron constituent, is a glycosylated carotenoid with potent anti-inflammatory and antioxidant activity. It shows several pharmacological properties, including protection against cardiovascular and pulmonary system disease, tumor cell proliferation, and neuroprotective activities. Numerous studies have shown the preventive and treatment effects of crocin on various cardiac disorders, including myocardial infarction, arrhythmias, and ischemia/reperfusion, as well as various respiratory disorders, including asthma, pulmonary fibrosis, and COPD.
Objectives: This paper reviews the documented results of studies on the beneficial effects of crocin on cardiopulmonary diseases.
Methods: The scientific papers were identified by research in Web of Science, PubMed, Scopus, and Science Direct databases. Search terms were combinations of "crocin", "cardiovascular", "pulmonary", "lung", "heart", and "natural products".
Results: Current evidence confirms that crocin is a potent preventive and therapeutic agent to decrease inflammation and oxidative damage to enhance the therapeutic outcomes in conditions related to cardiopulmonary problems.
Conclusion: These desirable properties promise the future use of crocin as a therapeutic agent in cardiovascular and respiratory diseases. However, further clinical trials and toxicological studies are needed in this regard.

Keywords

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