Abstract
Methods: The experimental rats were divided into five groups: control group, Isoprenaline (ISO) group, GW9662 as PPARγ antagonist+ISO, crocin+ISO group, and GW9662+crocin+ISO group. Isoprenaline was injected to induce myocardial ischemia.
Results: Findings showed that ISO and GW9662 increased Bax and caspase-3 gene expression and cardiac Creatine Phosphokinase (CPK) marker but decreased Bcl2. Crocin alleviated the expression of Bax and caspase-3 while increased Bcl2. It also reduced CPK levels in serum. However, GW9662 reversed these effects.
Conclusion: According to results, crocin may regulate apoptosis through PPARγ activation.
Keywords
Bax Caspase-3 Creatine Phosphokinase (CPK) Crocin Myocardial ischemia GW9662