A Comprehensive Review on Efficacy of Leukocyte and Platelet-rich Fibrin (L-PRF) Administration in Reconstruction of Oral and Maxillofacial Structures

1Department of Oral and Maxillofacial Surgery, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Imam Khomeini Hospital, Ahvaz, Iran

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Jundishapur Journal of Physiology:Vol. 2, issue 2; 69-81

Published online:Jul 21, 2022

Article type:Research Article

Received:Jun 29, 2022

Accepted:Jul 18, 2022

How to Cite:Shahrokh RaiesianAmir Danial Pour AhmadiyehMahdis Masoud RadA Comprehensive Review on Efficacy of Leukocyte and Platelet-rich Fibrin (L-PRF) Administration in Reconstruction of Oral and Maxillofacial Structures.Jundishapur J Physiol.2(2):e148765.https://doi.org/10.3295/JJP.2023.2.2.69.

Abstract

Several studies have shown that growth factors are effective in soothing inflammatory processes involved in the initial hemostasis phase of wound healing. Leukocyte and platelet-rich fibrin (L-PRF) is the second generation of concentrated platelets that have been shown to stimulate the proliferation of osteoblasts, gingival fibroblasts, and periodontal ligament cells. Rich platelet components have an immune function and antibacterial properties, which play a critical role in the wound healing process. The present study aimed to review the reported documents on L-PRF administration in regeneration and wound healing of oral and maxillofacial surgeries. The research was performed using well-known medical databases to find controlled clinical trials that used L-PRF as a co-treatment strategy during oral and maxillofacial surgeries. Eligible articles published between 2000 and 2022 in PubMed, Web of Science, Science Direct, and Scopus databases were selected for this review. According to the results of this study, L-PRF has significant effectiveness as a maxillofacial regenerative therapy by improving para-clinical parameters after surgery. However, more clinical practice and additional research are essential for the development of this complementary treatment method.

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Author(s):

Shahrokh Raiesian:[PubMed][Scholar]
Amir Danial Pour Ahmadiyeh:[PubMed][Scholar]
Mahdis Masoud Rad:[PubMed][Scholar]