Protective Effect of Trimetazidine on Kidney Dysfunction: A Review of Experimental Evidence

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Jundishapur Journal of Physiology:Vol. 2, issue 2; 90-98

Published online:Dec 05, 2022

Article type:Research Article

Received:Sep 25, 2021

Accepted:Jan 15, 2022

How to Cite:Negin AminiMohammad BadaviProtective Effect of Trimetazidine on Kidney Dysfunction: A Review of Experimental Evidence.Jundishapur J Physiol.2(2):e148767.https://doi.org/10.3295/JJP.2023.2.2.90.

Abstract

Background and Objectives: Acute kidney injury is the main cause of morbidity and mortality in the worldwide that is accompanied by short-term and long-term complications, including chronic kidney disease, end-stage renal disease, and ultimately death. Various mechanisms are involved in renal dysfunction, including oxidative stress, inflammatory responses, apoptosis, fibrosis, and mitochondrial dysfunction. Trimetazidine as a drug with free radical oxygen scavenging property represents to be more invaluable against acute kidney injury. Trimetazidine is considered as an anti-ischemic drug in the treatment of cardiac diseases which has been documented pharmacologic effects such as antioxidant, anti-apoptotic, and anti-inflammatory properties in renal ischemia-reperfusion injury, diabetic nephropathy, and nephrotoxicity models.
Subjects and Methods: This review underlines the nephroprotective effect of trimetazidine on kidney injury models. For this review, the articles have been searched in the databases, including PubMed, Scopus, Web of science, and Google Scholar. The search process was provided using these keywords: “Trimetazidine”, “kidney”, “nephrotoxicity”, “renal ischemia – reperfusion injury”, and “Protective.”
Results: Present study validates which trimetazidine as a potential agent alleviates kidney dysfunction in experimental models through several mechanisms.
Conclusion: Trimetazidine could be considered as promising candidate to treat a variety of kidney diseases in the future.

Keywords

Trimetazidine

Oxidative Stress

Kidney injury

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Author(s):

Negin Amini:[PubMed][Scholar]
Mohammad Badavi:[PubMed][Scholar]