Protective Effect of Vitamin E against Polyvinyl Chloride Induced Damages and Oxidative Stress in Rat Testicular Tissue

Abbas  Sadeghi; Farah  Farokhi; Gholamreza  Najafi; Ali  Shalizar Jalali

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Protective Effect of Vitamin E against Polyvinyl Chloride Induced Damages and Oxidative Stress in Rat Testicular Tissue

Author(s):

Abbas Sadeghi^1,*,

Farah Farokhi¹,

Gholamreza Najafi²,

Ali Shalizar Jalali²

1Dept. of Biology, Faculty of Science, Urmia University, Urmia, Iran

2Dept. of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 21, issue 3; e69272

Published online:Dec 30, 2017

Article type:Research Article

Received:Nov 07, 2017

Accepted:Nov 07, 2017

How to Cite:Abbas SadeghiFarah FarokhiGholamreza NajafiAli Shalizar JalaliProtective Effect of Vitamin E against Polyvinyl Chloride Induced Damages and Oxidative Stress in Rat Testicular Tissue.J Kermanshah Univ Med Sci.21(3):e69272.

Abstract

Introduction: Numerous studies suggest that polyvinyl chloride (PVC) has adverse effects on male sexual function and testicular tissue. Vitamin E (Vit E) is a dietary compound with antioxidant scavenging function for toxic free radicals.

Methods: In this experimental study, 36 male Wistar rats were randomly divided into six groups (n=6) including control, Vit E (150 mg/kg/bw/day), PVC (200 mg/kg/bw/day), PVC (1000 mg/kg/bw/day), PVC (200 mg/kg/bw/day) + Vit E (150 mg/kg/bw/day), PVC (1000 mg/kg/bw/day) + Vit E (150 mg/kg/bw/day). The administration route was oral and experiment lasted 40 days. Each rat was weighed at the beginning and at the end of the experiment. Left testis was transferred to 10% formalin. The right testis was transferred to -70 ◦C for determining oxidative stress markers. Data were analyzed in SPSS software using Tukey test.

Results: Oral administration of PVC significantly decreased body and testes weights in the male rats. Furthermore, PVC significantly reduced height of germinal epithelium, diameter of seminiferous tubules, number of Leydig cells as well as catalase and total antioxidant capacity levels (p<0/05). However, Vit E minimized PVC-induced testicular toxicities.

Conclusion: Exposure to PVC can cause testicular damage, while Vit E, as an antioxidant, may reduce destructive effects of PVC in rat testis.

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